Epilepsy is common in patients with brain tumors. Patients presenting seizures as the first sign of a malignant glioma are at increased risk of recurrent seizures despite treatment with antiepileptic drugs. However, little is known about the incidence of epilepsy in the last stage of disease and in the end-of-life phase of brain tumor patients. We retrospectively analyzed the incidence of seizures in the last months of life in a series of patients affected by high-grade gliomas who were assisted at home during the whole course of the disease until death. A total of 157 patients were available for analysis. Of these patients, 58 (36.9 %) presented seizures in the last month before death. The risk of seizures in the end-of-life phase is higher in patients presenting previous history of epilepsy, particularly in patients with late-onset epilepsy. Out of the 58 patients presenting seizures in the last month of life, 86.2 % had previously had seizures and 13.8 % were seizure free. Most patients may encounter swallowing difficulties in taking anticonvulsants orally due to dysphagia and disturbances of consciousness, thus anticonvulsant treatment needs to be modified in advance. Loss of seizure control in the end-of-life phase may influence the quality of life of patients and their caregivers. © 2012 Springer Science+Business Media New York.

Epilepsy in the end-of-life phase in patients with high-grade gliomas / Andrea, Pace; Villani, Veronica; Cherubino Di, Lorenzo; Lara, Guariglia; Marta, Maschio; Alfredo, Pompili; Carmine Maria, Carapella. - In: JOURNAL OF NEURO-ONCOLOGY. - ISSN 0167-594X. - 111:1(2013), pp. 83-86. [10.1007/s11060-012-0993-2]

Epilepsy in the end-of-life phase in patients with high-grade gliomas

VILLANI, VERONICA;
2013

Abstract

Epilepsy is common in patients with brain tumors. Patients presenting seizures as the first sign of a malignant glioma are at increased risk of recurrent seizures despite treatment with antiepileptic drugs. However, little is known about the incidence of epilepsy in the last stage of disease and in the end-of-life phase of brain tumor patients. We retrospectively analyzed the incidence of seizures in the last months of life in a series of patients affected by high-grade gliomas who were assisted at home during the whole course of the disease until death. A total of 157 patients were available for analysis. Of these patients, 58 (36.9 %) presented seizures in the last month before death. The risk of seizures in the end-of-life phase is higher in patients presenting previous history of epilepsy, particularly in patients with late-onset epilepsy. Out of the 58 patients presenting seizures in the last month of life, 86.2 % had previously had seizures and 13.8 % were seizure free. Most patients may encounter swallowing difficulties in taking anticonvulsants orally due to dysphagia and disturbances of consciousness, thus anticonvulsant treatment needs to be modified in advance. Loss of seizure control in the end-of-life phase may influence the quality of life of patients and their caregivers. © 2012 Springer Science+Business Media New York.
2013
anticonvulsant drugs; brain tumor; end of life; epilepsy; high-grade gliomas
01 Pubblicazione su rivista::01a Articolo in rivista
Epilepsy in the end-of-life phase in patients with high-grade gliomas / Andrea, Pace; Villani, Veronica; Cherubino Di, Lorenzo; Lara, Guariglia; Marta, Maschio; Alfredo, Pompili; Carmine Maria, Carapella. - In: JOURNAL OF NEURO-ONCOLOGY. - ISSN 0167-594X. - 111:1(2013), pp. 83-86. [10.1007/s11060-012-0993-2]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/510311
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