In this paper mixtures of two biocompatible polymers, dextran methacrylate (DEX-MA) with different molecular weights and scleroglucan (Scl), in its native form and as carboxymethyl derivative (Scl-CM), were tested as injectable and in situ cross-linkable systems. Rheological and texture analyses were carried out to better investigate the behavior of this kind of matrices. The combination of these polymers is able to assure adequate mechanical properties, suitable for biomedical applications. In addition swelling studies and in vitro release studies of three different biomolecules were also carried out. (C) 2013 Elsevier Ltd. All rights reserved.
Novel injectable and in situ cross-linkable hydrogels of dextran methacrylate and scleroglucan derivatives: Preparation and characterization / Corrente, Federica; Hend M., Abu Amara; Pacelli, Settimio; Paolicelli, Patrizia; Casadei, Maria Antonietta. - In: CARBOHYDRATE POLYMERS. - ISSN 0144-8617. - ELETTRONICO. - 92:2(2013), pp. 1033-1039. [10.1016/j.carbpol.2012.10.018]
Novel injectable and in situ cross-linkable hydrogels of dextran methacrylate and scleroglucan derivatives: Preparation and characterization
CORRENTE, FEDERICA;PACELLI, SETTIMIO;PAOLICELLI, PATRIZIA;CASADEI, Maria Antonietta
2013
Abstract
In this paper mixtures of two biocompatible polymers, dextran methacrylate (DEX-MA) with different molecular weights and scleroglucan (Scl), in its native form and as carboxymethyl derivative (Scl-CM), were tested as injectable and in situ cross-linkable systems. Rheological and texture analyses were carried out to better investigate the behavior of this kind of matrices. The combination of these polymers is able to assure adequate mechanical properties, suitable for biomedical applications. In addition swelling studies and in vitro release studies of three different biomolecules were also carried out. (C) 2013 Elsevier Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
