DSC evidence of the interaction and absorption of 3,4-Secoisopimar-4(18),7,15-trien-3-oic acid by biomembrane model

3,4-Secoisopimar-4(18),7,15-trien-3-oic acid is a diterpenoid contained in the aerial parts of Salvia cinnabarina M. Martens et Galeotti which has been proved to inhibit the effect of some known mutagens, in several bacterial strains, acting as a desmutagenic agent. In order to evaluate if 3,4-Secoisopimar-4(18),7,15-trien-3-oic inactivate the mutagen in intra- or extracellular compartment, present work investigated the interaction between the test substance and the biological membrane in a model of biomembrane, represented by multilamellar vesicles of dimyristoylphosphatidylcholine, using differential scanning calorimetry. The results obtained indicate a strong interaction of the examined diterpenoid with the model of biomembrane and that its absorption is quite improved by a lipophilic carrier. (C) 2012 Elsevier B.V. All rights reserved.