PURPOSE: Our aim was to retrospectively analyse a series of patients with anal cancer treated with curative intent at a single institute in terms of survival and local disease control. MATERIALS AND METHODS: Forty-two patients with anal cancer were treated with primary radiotherapy with or without concurrent chemotherapy. The influence of the prognostic factors on overall (OS), disease-free (DFS), disease-specific (DSS), colostomy-free (CFS) and metastasis-free (MFS) survival was evaluated. RESULTS: Nine patients had stage I, 15 stage II, four stage IIIA and 14 stage IIIB disease. Tumour progression/ persistence occurred in five patients (12\%). The 5-year OS, DSS, DFS, CFS and MFS were 72.7\%, 84.2\%, 85.7\%, 81.1\% and 87.1\%, respectively. On univariate analysis, T stage emerged as highly significant for OS, DSS, CFS and DFS, whereas N status was a significant prognostic factor for DSS. On multivariate analysis, T stage was a significant prognostic factor for OS and CFS. CONCLUSIONS: Our data support the view that combined chemoradiation treatment of anal cancer is feasible and may provide survival benefits with an acceptable rate of adverse effects. We should consider T and N stages as important prognostic factors for survival.

[Curative radiotherapy in patients with anal cancer: clinical outcomes and prognostic factors in a single-institution experience.] / Osti, Mattia Falchetto; L., Agolli; Scaringi, Claudia; S., Bracci; G., Minniti; MAURIZI ENRICI, Riccardo. - In: LA RADIOLOGIA MEDICA. - ISSN 0033-8362. - STAMPA. - (2012). [10.1007/s11547-012-0900-0]

[Curative radiotherapy in patients with anal cancer: clinical outcomes and prognostic factors in a single-institution experience.]

OSTI, Mattia Falchetto;SCARINGI, CLAUDIA;G. Minniti;MAURIZI ENRICI, Riccardo
2012

Abstract

PURPOSE: Our aim was to retrospectively analyse a series of patients with anal cancer treated with curative intent at a single institute in terms of survival and local disease control. MATERIALS AND METHODS: Forty-two patients with anal cancer were treated with primary radiotherapy with or without concurrent chemotherapy. The influence of the prognostic factors on overall (OS), disease-free (DFS), disease-specific (DSS), colostomy-free (CFS) and metastasis-free (MFS) survival was evaluated. RESULTS: Nine patients had stage I, 15 stage II, four stage IIIA and 14 stage IIIB disease. Tumour progression/ persistence occurred in five patients (12\%). The 5-year OS, DSS, DFS, CFS and MFS were 72.7\%, 84.2\%, 85.7\%, 81.1\% and 87.1\%, respectively. On univariate analysis, T stage emerged as highly significant for OS, DSS, CFS and DFS, whereas N status was a significant prognostic factor for DSS. On multivariate analysis, T stage was a significant prognostic factor for OS and CFS. CONCLUSIONS: Our data support the view that combined chemoradiation treatment of anal cancer is feasible and may provide survival benefits with an acceptable rate of adverse effects. We should consider T and N stages as important prognostic factors for survival.
2012
01 Pubblicazione su rivista::01a Articolo in rivista
[Curative radiotherapy in patients with anal cancer: clinical outcomes and prognostic factors in a single-institution experience.] / Osti, Mattia Falchetto; L., Agolli; Scaringi, Claudia; S., Bracci; G., Minniti; MAURIZI ENRICI, Riccardo. - In: LA RADIOLOGIA MEDICA. - ISSN 0033-8362. - STAMPA. - (2012). [10.1007/s11547-012-0900-0]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/506865
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