A poly 2-hydroxyethyl methacrylate (pHEMA) hydrogel coated with ordered methylene chains forming an ultrasound-responsive coating was developed and employed to load the antibiotic ciprofloxacin. The polymer was able to retain the antibiotic in the absence of ultrasound but showed a significant drug release when low intensity ultrasound was applied. The use of this system may open interesting perspectives for future development of medical devices sensitive to external ultrasonic impulses, capable of treating or preventing biofilm growth via “on demand” drug release.
Controlled ultrasonic antibiotic release from hydrogel coatings for biofilm prevention / Francolini, Iolanda; P., Norris; K., Vanburen; M., Noble; B., Ratner; G., Donelli; P., Stoodley. - STAMPA. - (2003), pp. 21-22. (Intervento presentato al convegno "Biofilms 2003 "Conference tenutosi a Victoria, British Columbia, Canada. nel November 1-6).
Controlled ultrasonic antibiotic release from hydrogel coatings for biofilm prevention.
FRANCOLINI, IOLANDA;
2003
Abstract
A poly 2-hydroxyethyl methacrylate (pHEMA) hydrogel coated with ordered methylene chains forming an ultrasound-responsive coating was developed and employed to load the antibiotic ciprofloxacin. The polymer was able to retain the antibiotic in the absence of ultrasound but showed a significant drug release when low intensity ultrasound was applied. The use of this system may open interesting perspectives for future development of medical devices sensitive to external ultrasonic impulses, capable of treating or preventing biofilm growth via “on demand” drug release.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
