Junctional complexes are important in maintaining epithelial cell polarity and cell-cell interactions and are known to be involved in tooth development; thus the purpose of the present study was to investigate the immunohistochemical profile of beta-catenin, gamma-catenin and P-cadherin in 41 epithelial odontogenic lesions (5 radicular cysts, 17 keratocystic odontogenic tumors, 3 dentigerous cysts, 6 calcifying odontogenic cysts, 9 ameloblastomas and one ameloblastic carcinoma). Positive immunostaining was obtained in all cystic lesions as well as in ameloblastomas for the three proteins. Weak staining of beta-catenin and gamma-catenin and absence of P-cadherin expression were observed in ameloblastic carcinoma. These results denote more cytodifferentiation of odontogenic epithelium in ameloblastoma and let us speculate that loss of P-cadherin expression may have a role in transition from benign (ameloblastoma) to malignant phenotype (ameloblastic carcinoma) . Nuclear and cytoplasmic expressions of beta-catenin in half of examined calcifying odontogenic cysts and in ameloblastomas and ameloblastic carcinoma cases suggest deregulation of this protein and reinforce the role of Wnt-beta-catenin- TCF-Lef pathway in the pathogenesis and/or behavior of such lesions.

ADHESION MOLECULES IN EPITHELIAL ODONTOGENIC LESIONS / D. C., Barreto; F., Carinci; L., LO RUSSO; F. J., Pimenta; P. F., Perdigão; L., DE MARCO; L., Guida; Romeo, Umberto; Polimeni, Antonella; R. S., Gomez; L., LO MUZIO. - In: EUROPEAN JOURNAL OF INFLAMMATION. - ISSN 1721-727X. - STAMPA. - 9:(2011), pp. 37-42.

ADHESION MOLECULES IN EPITHELIAL ODONTOGENIC LESIONS.

ROMEO, Umberto;POLIMENI, Antonella;
2011

Abstract

Junctional complexes are important in maintaining epithelial cell polarity and cell-cell interactions and are known to be involved in tooth development; thus the purpose of the present study was to investigate the immunohistochemical profile of beta-catenin, gamma-catenin and P-cadherin in 41 epithelial odontogenic lesions (5 radicular cysts, 17 keratocystic odontogenic tumors, 3 dentigerous cysts, 6 calcifying odontogenic cysts, 9 ameloblastomas and one ameloblastic carcinoma). Positive immunostaining was obtained in all cystic lesions as well as in ameloblastomas for the three proteins. Weak staining of beta-catenin and gamma-catenin and absence of P-cadherin expression were observed in ameloblastic carcinoma. These results denote more cytodifferentiation of odontogenic epithelium in ameloblastoma and let us speculate that loss of P-cadherin expression may have a role in transition from benign (ameloblastoma) to malignant phenotype (ameloblastic carcinoma) . Nuclear and cytoplasmic expressions of beta-catenin in half of examined calcifying odontogenic cysts and in ameloblastomas and ameloblastic carcinoma cases suggest deregulation of this protein and reinforce the role of Wnt-beta-catenin- TCF-Lef pathway in the pathogenesis and/or behavior of such lesions.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/505667
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