Age-related changes of the catecholaminergic nerve fibers of the trachea, bronchial smooth muscle, lung capillaries and bronchus-associated lymphoid tissue (BALT) were studied in male Wistar rats aged 3 months (young), 12 months (adult) and 24 months (old/aged). Catecholamine histo- and immuno-fluorescence techniques were used, associated with image analysis and high pressure liquid chromatography with electrochemical detection of nor-epinephrine (nor-adrenaline). In young rats, blue-green fluorescent nerve fibers supply the trachea-bronchial smooth muscle and tracheal and bronchial glands. These structures are innervated by a delicate network of nerve fibers, being rich in varicosities. Pulmonary capillaries are sparsely innervated. The highest nor-epinephrine concentration was found in the trachea and bronchi, followed by BALT. The density and the pattern of noradrenergic nerve fibers of the trachea-bronchial tree or of the pulmonary vessels were similar in young and adult rats. In aged rats, a loss of noradrenergic nerve fibers, involving primarily the supply to the smooth muscle of the trachea-bronchial tree, was observed. Fluorescence microscopic techniques demonstrated a higher sensitivity than nor-epinephrine assay in detecting changes of the sympathetic nerve supply of the trachea-bronchial tree, pulmonary vessels and BALT. The possible significance of reduced noradrenergic nerve supply of the trachea-bronchial-pulmonary tree in aged rats is discussed.
Catecholaminergic nerve fibers in bronchus-associated lymphoid tissue: age-related changes / Cavallotti, C; Tranquilli Leali, Fm; Galea, Nicola; Tonnarini, Gian Franco. - In: ARCHIVES OF GERONTOLOGY AND GERIATRICS. - ISSN 0167-4943. - STAMPA. - 39(2004), pp. 59-68. [10.1016/j.archger.2003.12.007]
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|Titolo:||Catecholaminergic nerve fibers in bronchus-associated lymphoid tissue: age-related changes|
|Data di pubblicazione:||2004|
|Citazione:||Catecholaminergic nerve fibers in bronchus-associated lymphoid tissue: age-related changes / Cavallotti, C; Tranquilli Leali, Fm; Galea, Nicola; Tonnarini, Gian Franco. - In: ARCHIVES OF GERONTOLOGY AND GERIATRICS. - ISSN 0167-4943. - STAMPA. - 39(2004), pp. 59-68. [10.1016/j.archger.2003.12.007]|
|Appartiene alla tipologia:||01a Articolo in rivista|