Functional Evaluation of Subjects Affected by Various Degree of Multiple Sclerosis

Objective: To investigate the physical fitness of an heterogeneous group of subjects affected by Multiple Sclerosis (MS) to correctly prescribe physical exercise. Subjects: Thirteen subjects with MS. Main Measures: Disability (EDSS), Fatigue perception (MFIS and BORG), Balance control (BERG), Aerobic fitness (6MWT), Maximal Voluntary Contraction (MCV) of selected muscle groups and differences between lower limbs (Delta MCV), trough Isometric dynamometry. Main Results: Subjects with highest EDSS had the lowest 6MWT R(2)=0,84, the lowest BERG: R(2)=0,61 and the lowest values of MCV of lover limb R(2)=0,30. Differences in MCV (Delta MCV) between right and left leg were 31,2 % +/- 30% (min 11%, max 100%), and were inversely correlated with BERG R(2)=0,40. Conclusion: Physical fitness in MS subjects is correlated with disability. An adequate increase in the physical fitness could decrease the disability and the progression of MS. Subjects affected by MS should regularly practice physical exercise including programmes to increase the level of aerobic fitness and resistance fitness, associated with coordination and balance exercises.