Chemical reactivity of asbestos tremolite from Italy and USA localities and Union Internationale Contre le Cancer (UICC) crocidolite was studied in relation to Fe content, oxidation state, and structural coordination. Direct correlation between amount of Fe 2+ at the exposed M(1) and M(2) sites of the amphibole structure and fiber chemical reactivity was established. The in vitro toxicity of the same samples was investigated on human alveolar A549 cell line. Relationship between crystal-chemical features and cell toxicity is not straightforward. UICC crocidolite has Fe content and chemical reactivity largely higher than that of tremolite samples, but all show comparable in vitro toxic potential. Results obtained evidenced that Fe topochemistry is not a primary factor for induced cell toxicity, though it accounts for asbestos chemical reactivity (and possibly genotoxicity). © 2011 Springer-Verlag.

Iron topochemistry, surface reactivity and in vitro toxicity of amphibole asbestos / Pacella, Alessandro; Andreozzi, Giovanni Battista; Jeanine, Fournier; Lorenzo, Stievano; Federica, Giantomassi; Guendalina, Lucarini; Maria Rita, Rippo; Armanda, Pugnaloni. - In: ANALYTICAL AND BIOANALYTICAL CHEMISTRY. - ISSN 1618-2642. - STAMPA. - 402:(2012), pp. 871-881. [10.1007/s00216-011-5525-y]

Iron topochemistry, surface reactivity and in vitro toxicity of amphibole asbestos

PACELLA, Alessandro;ANDREOZZI, Giovanni Battista;
2012

Abstract

Chemical reactivity of asbestos tremolite from Italy and USA localities and Union Internationale Contre le Cancer (UICC) crocidolite was studied in relation to Fe content, oxidation state, and structural coordination. Direct correlation between amount of Fe 2+ at the exposed M(1) and M(2) sites of the amphibole structure and fiber chemical reactivity was established. The in vitro toxicity of the same samples was investigated on human alveolar A549 cell line. Relationship between crystal-chemical features and cell toxicity is not straightforward. UICC crocidolite has Fe content and chemical reactivity largely higher than that of tremolite samples, but all show comparable in vitro toxic potential. Results obtained evidenced that Fe topochemistry is not a primary factor for induced cell toxicity, though it accounts for asbestos chemical reactivity (and possibly genotoxicity). © 2011 Springer-Verlag.
2012
in vitro toxicity; asbestos amphiboles; fe topochemistry; surface reactivity; lipid peroxidation
01 Pubblicazione su rivista::01a Articolo in rivista
Iron topochemistry, surface reactivity and in vitro toxicity of amphibole asbestos / Pacella, Alessandro; Andreozzi, Giovanni Battista; Jeanine, Fournier; Lorenzo, Stievano; Federica, Giantomassi; Guendalina, Lucarini; Maria Rita, Rippo; Armanda, Pugnaloni. - In: ANALYTICAL AND BIOANALYTICAL CHEMISTRY. - ISSN 1618-2642. - STAMPA. - 402:(2012), pp. 871-881. [10.1007/s00216-011-5525-y]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/505127
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