The authors evaluated the in vivo effects of the new drug Cisapride on gastrointestinal hormone release in the mini-pig. Cisapride has been reported to stimulate and coordinate peristalsis of the GI tract. Selective endoluminal perfusion with Cisapride solution of the isolated but not denervated gastric antrum, duodenum and distal ileum demonstrated a significant increase of gastrin levels following perfusion of the gastric antrum and a decrease in vasoactive intestinal peptide following perfusion of the duodenum, only at very high doses.

Digestive tract endoluminal perfusion of cisapride (R 51619) and effects on gastrointestinal hormone levels in anaesthetized pigs / U., Caruso; Lezoche, Emanuele; M., Elli; G., Tisone; Mariani, Paola; D'Alessandro, Mariadomenica; Cravotto, Elena; P. A., Lombardo; M., Tavolaro; M., Silvaroli. - In: DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH. - ISSN 0378-6501. - STAMPA. - 11:10(1985), pp. 679-682.

Digestive tract endoluminal perfusion of cisapride (R 51619) and effects on gastrointestinal hormone levels in anaesthetized pigs.

LEZOCHE, Emanuele;MARIANI, Paola;D'ALESSANDRO, Mariadomenica;CRAVOTTO, Elena;
1985

Abstract

The authors evaluated the in vivo effects of the new drug Cisapride on gastrointestinal hormone release in the mini-pig. Cisapride has been reported to stimulate and coordinate peristalsis of the GI tract. Selective endoluminal perfusion with Cisapride solution of the isolated but not denervated gastric antrum, duodenum and distal ileum demonstrated a significant increase of gastrin levels following perfusion of the gastric antrum and a decrease in vasoactive intestinal peptide following perfusion of the duodenum, only at very high doses.
1985
animals; gastrointestinal hormone; • pancreatic polypeptide/blood
01 Pubblicazione su rivista::01a Articolo in rivista
Digestive tract endoluminal perfusion of cisapride (R 51619) and effects on gastrointestinal hormone levels in anaesthetized pigs / U., Caruso; Lezoche, Emanuele; M., Elli; G., Tisone; Mariani, Paola; D'Alessandro, Mariadomenica; Cravotto, Elena; P. A., Lombardo; M., Tavolaro; M., Silvaroli. - In: DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH. - ISSN 0378-6501. - STAMPA. - 11:10(1985), pp. 679-682.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/504125
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