We examined the relationship between blood volume, mean haemoglobin maintained and transfusion requirement in an extensive series (166 cases) of uniformly treated patients with homozygous beta-thalassaemia. The blood volume is increased in all the subjects and this increase appears inversely proportional to the mean haemoglobin level maintained. When this is above 12 g/dl, the blood volume is nearly normal. The transfusion requirement of patients kept between 10 and 14 g/dl is constant. Maintenance of a high haemoglobin level in thalassaemic patients inhibits erythropoiesis to a considerable degree with a reduction of the haemopoietic tissue and hence of the total blood volume.
Correlation between transfusion requirement, blood volume and haemoglobin level in homozygous beta-thalassaemia / V., Gabutti; A., Piga; Fortina, Paolo; R., Miniero; P., Nicola. - In: ACTA HAEMATOLOGICA. - ISSN 0001-5792. - STAMPA. - 64:2(1980), pp. 103-108.
Correlation between transfusion requirement, blood volume and haemoglobin level in homozygous beta-thalassaemia.
FORTINA, PAOLO;
1980
Abstract
We examined the relationship between blood volume, mean haemoglobin maintained and transfusion requirement in an extensive series (166 cases) of uniformly treated patients with homozygous beta-thalassaemia. The blood volume is increased in all the subjects and this increase appears inversely proportional to the mean haemoglobin level maintained. When this is above 12 g/dl, the blood volume is nearly normal. The transfusion requirement of patients kept between 10 and 14 g/dl is constant. Maintenance of a high haemoglobin level in thalassaemic patients inhibits erythropoiesis to a considerable degree with a reduction of the haemopoietic tissue and hence of the total blood volume.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.