Abstract A reinvestigation of the aerial parts of Calendula arvensis afforded, in addition to the oleanolic acid glycosides 1-4(4), the new glycoside 5 whose structure was elucidated by spectral and chemical studies and determined as 3-O-{β-D-galactopyranosyl-(1→3)[β-D-glucopyranosyl-(1→4)]-β-D-glucopyranosyl}oleanolic acid (28→1)-β-D-glucopyranosyl ester. Furthermore, some antiviral tests were performed on glycosides 1-5 and on 5a, the hydrolysis product of 5, towards vesicular Stomatitis virus (VSV) and rhinovirus (HRV) infection in cell cultures. An inhibitory effect against VSV multiplication was observed for all the Compounds tested while HRV replication was significantly affected only by compound 3.

structure and in vitro antiviral activity of triterpenoid saponins from calendula arvensis / de tommasi, N; Conti, Cinzia; Stein, m. l.; Pizza, C.. - In: PLANTA MEDICA. - ISSN 0032-0943. - 57:(1992), pp. 293-298. [10.1055/s-2006-960084]

structure and in vitro antiviral activity of triterpenoid saponins from calendula arvensis

CONTI, Cinzia;
1992

Abstract

Abstract A reinvestigation of the aerial parts of Calendula arvensis afforded, in addition to the oleanolic acid glycosides 1-4(4), the new glycoside 5 whose structure was elucidated by spectral and chemical studies and determined as 3-O-{β-D-galactopyranosyl-(1→3)[β-D-glucopyranosyl-(1→4)]-β-D-glucopyranosyl}oleanolic acid (28→1)-β-D-glucopyranosyl ester. Furthermore, some antiviral tests were performed on glycosides 1-5 and on 5a, the hydrolysis product of 5, towards vesicular Stomatitis virus (VSV) and rhinovirus (HRV) infection in cell cultures. An inhibitory effect against VSV multiplication was observed for all the Compounds tested while HRV replication was significantly affected only by compound 3.
1992
01 Pubblicazione su rivista::01a Articolo in rivista
structure and in vitro antiviral activity of triterpenoid saponins from calendula arvensis / de tommasi, N; Conti, Cinzia; Stein, m. l.; Pizza, C.. - In: PLANTA MEDICA. - ISSN 0032-0943. - 57:(1992), pp. 293-298. [10.1055/s-2006-960084]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/502548
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