Biologically relevant effects, as beginning of cellular apoptotic states or tumors growth inhibition have been associated with the exposure of cellular lines and animal tissues to nanosecond pulsed electric fields. In this context, cell membrane is considered as one of the main interaction target and membrane nano-poration is the most relevant conformational observed effects. The intensity of such phenomenon depends mostly on duration, amplitude and shape of the delivered pulse. Therefore, in this paper, authors aim to evaluate membrane electric field and pore density as a tool to predict optimal signal waveforms and minimal energy required for effective treatments.
Nanopulse Microdosimetry on a Single Cell: an Investigation on Waveform Efficiency / Silvia Di, Lecce; Caterina, Merla; Paffi, Alessandra; Delia Arnaud, Cormos; Apollonio, Francesca; Philippe, Leveque; Liberti, Micaela. - ELETTRONICO. - (2011). (Intervento presentato al convegno 10th International Congress of the European Bioelectromagnetics Association tenutosi a Roma nel February 21-24).
Nanopulse Microdosimetry on a Single Cell: an Investigation on Waveform Efficiency
PAFFI, ALESSANDRA;APOLLONIO, Francesca;LIBERTI, Micaela
2011
Abstract
Biologically relevant effects, as beginning of cellular apoptotic states or tumors growth inhibition have been associated with the exposure of cellular lines and animal tissues to nanosecond pulsed electric fields. In this context, cell membrane is considered as one of the main interaction target and membrane nano-poration is the most relevant conformational observed effects. The intensity of such phenomenon depends mostly on duration, amplitude and shape of the delivered pulse. Therefore, in this paper, authors aim to evaluate membrane electric field and pore density as a tool to predict optimal signal waveforms and minimal energy required for effective treatments.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
