Aim of this work is to theoretically treat a simple molecular system, i.e. a neutral micelle with an encapsulated organic solute, to study a new class of molecular vectors for innovative drug delivery techniques. Simple systems like micelles represent a good choice for the possibility to be experimentally modeled and to be sensible to specific physical agents and consequently activate the delivery. The efficacy of a stimuli-response induced by a E-field perturbation is investigated and results indicate that exogenous electric field of sufficient strength can modify biophysical properties of the simulated system arriving to possibly control a chemical reaction.
Theoretical Study of a Simple Drug Delivery Vector: E-field Influence upon Chemical Reaction in Micelle / Marracino, Paolo; Liberti, Micaela; Massimiliano, Aschi; Andrea, Amadei; D'Inzeo, Guglielmo; Apollonio, Francesca. - ELETTRONICO. - (2011). (Intervento presentato al convegno 10th International Congress of the European Bioelectromagnetics Association tenutosi a Roma nel February 21-24).
Theoretical Study of a Simple Drug Delivery Vector: E-field Influence upon Chemical Reaction in Micelle
MARRACINO, PAOLO;LIBERTI, Micaela;D'INZEO, Guglielmo;APOLLONIO, Francesca
2011
Abstract
Aim of this work is to theoretically treat a simple molecular system, i.e. a neutral micelle with an encapsulated organic solute, to study a new class of molecular vectors for innovative drug delivery techniques. Simple systems like micelles represent a good choice for the possibility to be experimentally modeled and to be sensible to specific physical agents and consequently activate the delivery. The efficacy of a stimuli-response induced by a E-field perturbation is investigated and results indicate that exogenous electric field of sufficient strength can modify biophysical properties of the simulated system arriving to possibly control a chemical reaction.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
