Protein functions and characteristics can highly differ from physiological conditions in presence of chemical, mechanical or electromagnetic stimuli. In this work we provide a rigorous picture of electric field effects on proteins behavior investigating, at atomistic details, the possible ways in which an external signal can be transduced into biochemical effects. Results from molecular dynamics (MD) simulations of a single superoxidismutase (SOD) enzyme in presence of high exogenous alternate electric fields will be discussed. © 2012 IEEE.
Signal transduction on enzymes: The Effect of electromagnetic field stimuli on superoxide dismutase (SOD) / Marracino, Paolo; M., Migliorati; Paffi, Alessandra; Liberti, Micaela; Denzi, Agnese; D'Inzeo, Guglielmo; Apollonio, Francesca. - (2012), pp. 5674-5677. (Intervento presentato al convegno 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 tenutosi a San Diego, CA nel 28 August 2012 through 1 September 2012) [10.1109/embc.2012.6347282].
Signal transduction on enzymes: The Effect of electromagnetic field stimuli on superoxide dismutase (SOD)
MARRACINO, PAOLO;PAFFI, ALESSANDRA;LIBERTI, Micaela;DENZI, AGNESE;D'INZEO, Guglielmo;APOLLONIO, Francesca
2012
Abstract
Protein functions and characteristics can highly differ from physiological conditions in presence of chemical, mechanical or electromagnetic stimuli. In this work we provide a rigorous picture of electric field effects on proteins behavior investigating, at atomistic details, the possible ways in which an external signal can be transduced into biochemical effects. Results from molecular dynamics (MD) simulations of a single superoxidismutase (SOD) enzyme in presence of high exogenous alternate electric fields will be discussed. © 2012 IEEE.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
