The cell membrane poration is one of the main assessed biological effects of nanosecond pulsed electric fields (nsPEF). This structural change of the cell membrane appears soon after the pulse delivery and lasts for a time period long enough to modify the electrical activity of excitable membranes in neurons. Inserting such a phenomenon in a Hodgkin and Huxley neuron model by means of an enhanced time varying conductance resulted in the temporary inhibition of the action potential generation. The inhibition time is a function of the level of poration, the pore resealing time and the background stimulation level of the neuron. Such results suggest that the neuronal activity may be efficiently modulated by the delivery of repeated pulses. This opens the way to the use of nsPEFs as a stimulation technique alternative to the conventional direct electric stimulation for medical applications such as chronic pain treatment.

Effects of Nanosecond Pulsed Electric Fields on the Activity of a Hodgkin and Huxley Neuron Model / Camera, Francesca; Paffi, Alessandra; C., Merla; Denzi, Agnese; Apollonio, Francesca; Marracino, Paolo; D'Inzeo, Guglielmo; Liberti, Micaela. - ELETTRONICO. - 2012:(2012), pp. 2567-2570. (Intervento presentato al convegno 34th Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS) tenutosi a San Diego, CA nel AUG 28-SEP 01, 2012) [10.1109/embc.2012.6346488].

Effects of Nanosecond Pulsed Electric Fields on the Activity of a Hodgkin and Huxley Neuron Model

CAMERA, FRANCESCA;PAFFI, ALESSANDRA;DENZI, AGNESE;APOLLONIO, Francesca;MARRACINO, PAOLO;D'INZEO, Guglielmo;LIBERTI, Micaela
2012

Abstract

The cell membrane poration is one of the main assessed biological effects of nanosecond pulsed electric fields (nsPEF). This structural change of the cell membrane appears soon after the pulse delivery and lasts for a time period long enough to modify the electrical activity of excitable membranes in neurons. Inserting such a phenomenon in a Hodgkin and Huxley neuron model by means of an enhanced time varying conductance resulted in the temporary inhibition of the action potential generation. The inhibition time is a function of the level of poration, the pore resealing time and the background stimulation level of the neuron. Such results suggest that the neuronal activity may be efficiently modulated by the delivery of repeated pulses. This opens the way to the use of nsPEFs as a stimulation technique alternative to the conventional direct electric stimulation for medical applications such as chronic pain treatment.
2012
34th Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS)
nanopulse; neuron model
04 Pubblicazione in atti di convegno::04b Atto di convegno in volume
Effects of Nanosecond Pulsed Electric Fields on the Activity of a Hodgkin and Huxley Neuron Model / Camera, Francesca; Paffi, Alessandra; C., Merla; Denzi, Agnese; Apollonio, Francesca; Marracino, Paolo; D'Inzeo, Guglielmo; Liberti, Micaela. - ELETTRONICO. - 2012:(2012), pp. 2567-2570. (Intervento presentato al convegno 34th Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS) tenutosi a San Diego, CA nel AUG 28-SEP 01, 2012) [10.1109/embc.2012.6346488].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/501929
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