Five patients with lymphoid blastic transformation of chronic myeloid leukemia have been treated with IL2 associated with Vincristine (VCR) plus Prednisone (PDN). Our study indicates that IL2 may be employed in the management of this disease without excessive toxicity at the higher doses in hospitalized patients and at the lower doses as outpatients. Concerning the therapeutic efficacy, our preliminary results indicate that IL2 might be useful in enhancing the chemosensitivity of the leukemic blasts. It remains to be seen if this will result in a rapid return of the CP and in a prolongation of survival.

IL-2 in the treatment of chronic myeloid leukemia after lymphoid blast crisis: a pilot study / Meloni, Giovanna; Foa, Roberto; Tosti, S; Vignetti, Marco; Gavosto, F; Mandelli, Franco. - In: HAEMATOLOGICA. - ISSN 0390-6078. - STAMPA. - 75:6(1990), pp. 502-505.

IL-2 in the treatment of chronic myeloid leukemia after lymphoid blast crisis: a pilot study

MELONI, Giovanna;FOA, Roberto;VIGNETTI, Marco;MANDELLI, Franco
1990

Abstract

Five patients with lymphoid blastic transformation of chronic myeloid leukemia have been treated with IL2 associated with Vincristine (VCR) plus Prednisone (PDN). Our study indicates that IL2 may be employed in the management of this disease without excessive toxicity at the higher doses in hospitalized patients and at the lower doses as outpatients. Concerning the therapeutic efficacy, our preliminary results indicate that IL2 might be useful in enhancing the chemosensitivity of the leukemic blasts. It remains to be seen if this will result in a rapid return of the CP and in a prolongation of survival.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/501654
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