The incidence of a hyperfibrinolytic state and its clinical significance in the clinical history of patients with liver cirrhosis (LC), are still being debated. This study reports the prevalence of hyperfibrinolysis and its relationship to clinical and laboratory features in 81 consecutive LC patients, 20 with A, 23 with B and 38 with C grade according to Child-Pugh's classification. In 28 LC patients (34.5%), a hyperfibrinolytic state was assessed by high circulating levels of fibrin(ogen) degradation products (FDP) (>10 ug/ml) and confirmed by increased levels of tissue plasminogen activator (t-PA) activity. In this patients' subgroup, significantly lower levels of prothrombin activity (Normotest) (p=0.0001), fibrinogen (p=0.001) and platelet count (p<0.03) more prolonged aPTT (p<0.001) and higher levels of serum bilirubin (p=0.0001) were found. Signs of hyperfibrinolysis were not found in class A patients, while 25% of elevated FDP were found in class B and 75% in class C patients; on the other hand (p=0.0001), 53 LC patients without hyperfibrinolysis were evenly distributed among Child-Pugh's classes. Finally, LC patients with hyperfibrinolysis had a significantly higher incidence of ascites (p=0.0001) and a major occurrence of previous gastrointestinal bleeding (p=0.001). The study shows that hyperfibrinolysis occurs prevalently in LC patients with severe liver failure and could represent an haemorrhagic risk factor, probably by reducing the activity of clotting factors.

PREVALENCE OF HYPERFIBRINOLYSIS IN PATIENTS WITH LIVER-CIRRHOSIS / Ferro, Domenico; C., Quintarelli; Saliola, Mirella; Alessandri, Cesare; Basili, Stefania; M. S., Bonavita; Violi, Francesco. - In: FIBRINOLYSIS. - ISSN 0268-9499. - STAMPA. - 7:1(1993), pp. 59-62. [10.1016/0268-9499(93)90056-2]

PREVALENCE OF HYPERFIBRINOLYSIS IN PATIENTS WITH LIVER-CIRRHOSIS

FERRO, Domenico;SALIOLA, Mirella;ALESSANDRI, Cesare;BASILI, Stefania;VIOLI, Francesco
1993

Abstract

The incidence of a hyperfibrinolytic state and its clinical significance in the clinical history of patients with liver cirrhosis (LC), are still being debated. This study reports the prevalence of hyperfibrinolysis and its relationship to clinical and laboratory features in 81 consecutive LC patients, 20 with A, 23 with B and 38 with C grade according to Child-Pugh's classification. In 28 LC patients (34.5%), a hyperfibrinolytic state was assessed by high circulating levels of fibrin(ogen) degradation products (FDP) (>10 ug/ml) and confirmed by increased levels of tissue plasminogen activator (t-PA) activity. In this patients' subgroup, significantly lower levels of prothrombin activity (Normotest) (p=0.0001), fibrinogen (p=0.001) and platelet count (p<0.03) more prolonged aPTT (p<0.001) and higher levels of serum bilirubin (p=0.0001) were found. Signs of hyperfibrinolysis were not found in class A patients, while 25% of elevated FDP were found in class B and 75% in class C patients; on the other hand (p=0.0001), 53 LC patients without hyperfibrinolysis were evenly distributed among Child-Pugh's classes. Finally, LC patients with hyperfibrinolysis had a significantly higher incidence of ascites (p=0.0001) and a major occurrence of previous gastrointestinal bleeding (p=0.001). The study shows that hyperfibrinolysis occurs prevalently in LC patients with severe liver failure and could represent an haemorrhagic risk factor, probably by reducing the activity of clotting factors.
1993
hyperfibrinolysis
01 Pubblicazione su rivista::01a Articolo in rivista
PREVALENCE OF HYPERFIBRINOLYSIS IN PATIENTS WITH LIVER-CIRRHOSIS / Ferro, Domenico; C., Quintarelli; Saliola, Mirella; Alessandri, Cesare; Basili, Stefania; M. S., Bonavita; Violi, Francesco. - In: FIBRINOLYSIS. - ISSN 0268-9499. - STAMPA. - 7:1(1993), pp. 59-62. [10.1016/0268-9499(93)90056-2]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/501060
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