Previous reports have suggested a correlation between autoimmunity and abortive axonal regeneration in mammalian CNS. In this study we investigated the effects of immunosuppressive treatment with Cyclosporine A (CyA) (2.5-5 mg/kg/day) on axonal regeneration after complete spinal transection in rats. Partial recovery of function was observed 30 days after surgery in rats treated with CyA, with the presence of incomplete spontaneous locomotion and a positive contact placing reaction. Restoration of somatosensory evoked potentials and positive retrograde fluorescent tracing were also observed. CyA reduced the autoimmune reaction which targeted components of the axons. These results provide further evidence of the role played by autoimmunity in blocking regeneration of fibre tracts in mammalian CNS.

Treatment with cyclosporine A promotes axonal regeneration in rats submitted to transverse section of the spinal cord--II--Recovery of function / Palladini, G; Caronti, B; Pozzessere, G; Teichner, A; Buttarelli, Francesca Romana; Morselli, E; Valle, E; Venturini, G; Fortuna, A; Pontieri, FRANCESCO ERNESTO. - In: JOURNAL OF BRAIN RESEARCH. - ISSN 0944-8160. - STAMPA. - 37:(1996), pp. 145-153.

Treatment with cyclosporine A promotes axonal regeneration in rats submitted to transverse section of the spinal cord--II--Recovery of function.

Caronti B;BUTTARELLI, Francesca Romana;PONTIERI, FRANCESCO ERNESTO
1996

Abstract

Previous reports have suggested a correlation between autoimmunity and abortive axonal regeneration in mammalian CNS. In this study we investigated the effects of immunosuppressive treatment with Cyclosporine A (CyA) (2.5-5 mg/kg/day) on axonal regeneration after complete spinal transection in rats. Partial recovery of function was observed 30 days after surgery in rats treated with CyA, with the presence of incomplete spontaneous locomotion and a positive contact placing reaction. Restoration of somatosensory evoked potentials and positive retrograde fluorescent tracing were also observed. CyA reduced the autoimmune reaction which targeted components of the axons. These results provide further evidence of the role played by autoimmunity in blocking regeneration of fibre tracts in mammalian CNS.
1996
01 Pubblicazione su rivista::01a Articolo in rivista
Treatment with cyclosporine A promotes axonal regeneration in rats submitted to transverse section of the spinal cord--II--Recovery of function / Palladini, G; Caronti, B; Pozzessere, G; Teichner, A; Buttarelli, Francesca Romana; Morselli, E; Valle, E; Venturini, G; Fortuna, A; Pontieri, FRANCESCO ERNESTO. - In: JOURNAL OF BRAIN RESEARCH. - ISSN 0944-8160. - STAMPA. - 37:(1996), pp. 145-153.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/500327
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 28
  • ???jsp.display-item.citation.isi??? 20
social impact