Environmental condition such as food restriction has been shown to produce sensitization to the stimulant and rewarding effects of amphetamine in the low responsive DBA/2J genotype. Here, we report that food-restricted DBA/2J mice lose the impulse-independent component of psychostimulant-induced dopamine release in the nucleus accumbens that is replaced totally by impulse-dependent dopamine release. These results indicate for the first time that the crucial effect of environment-induced sensitization is a dramatic increase of the impulse dependent component.
Environment makes amphetamine-induced dopamine release in the nucleus Accumbens totally impulse-dependent / Ventura, Rossella; PUGLISI ALLEGRA, Stefano. - In: SYNAPSE. - ISSN 0887-4476. - 58:3(2005), pp. 211-214. [10.1002/syn.20197]
Environment makes amphetamine-induced dopamine release in the nucleus Accumbens totally impulse-dependent
VENTURA, Rossella;PUGLISI ALLEGRA, Stefano
2005
Abstract
Environmental condition such as food restriction has been shown to produce sensitization to the stimulant and rewarding effects of amphetamine in the low responsive DBA/2J genotype. Here, we report that food-restricted DBA/2J mice lose the impulse-independent component of psychostimulant-induced dopamine release in the nucleus accumbens that is replaced totally by impulse-dependent dopamine release. These results indicate for the first time that the crucial effect of environment-induced sensitization is a dramatic increase of the impulse dependent component.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
