Background.We report a leiomyosarcoma of the uterus, an uncommon tumor with a very aggressive course and poor prognosis due to the fact that, despite complete resection, it recurs with micrometastases. The most common metastatic sites are the lung, intraperitoneal, pelvic and paraaortic lymph nodes, and liver. Brain and skull metastases are very rare. Case. A 57-year-old woman underwent a hysterectomy and bilateral salpingooophorectomy for a grade T2N0M0 uterine leiomyosarcoma. There was no evidence of other lesions. Three months later a total-body PET scan demonstrated the presence of metastases in both lungs, and the patient was started on chemotherapy. One year later a cranialMRI demonstrated a brain metastasis to the temporal lobe. Emergency complete resection of the recurrence was performed, followed by whole-brain radiation and adjuvant chemotherapy. Conclusions. Given the limited treatment options, the gold standard for uterine leiomyosarcoma brain metastasis is total surgical removal. Chemotherapy and radiation therapy may provide only palliative benefit.

Uterine leiomyosarcoma metastatic to the brain: case report / Melone, ANGELINA GRAZIELLA; D'Elia, Alessandro; Brogna, Christian; Salvati, Maurizio. - In: TUMORI. - ISSN 2038-2529. - STAMPA. - 94:6(2008), pp. 856-860.

Uterine leiomyosarcoma metastatic to the brain: case report

MELONE, ANGELINA GRAZIELLA;D'ELIA, ALESSANDRO;BROGNA, CHRISTIAN;SALVATI, Maurizio
2008

Abstract

Background.We report a leiomyosarcoma of the uterus, an uncommon tumor with a very aggressive course and poor prognosis due to the fact that, despite complete resection, it recurs with micrometastases. The most common metastatic sites are the lung, intraperitoneal, pelvic and paraaortic lymph nodes, and liver. Brain and skull metastases are very rare. Case. A 57-year-old woman underwent a hysterectomy and bilateral salpingooophorectomy for a grade T2N0M0 uterine leiomyosarcoma. There was no evidence of other lesions. Three months later a total-body PET scan demonstrated the presence of metastases in both lungs, and the patient was started on chemotherapy. One year later a cranialMRI demonstrated a brain metastasis to the temporal lobe. Emergency complete resection of the recurrence was performed, followed by whole-brain radiation and adjuvant chemotherapy. Conclusions. Given the limited treatment options, the gold standard for uterine leiomyosarcoma brain metastasis is total surgical removal. Chemotherapy and radiation therapy may provide only palliative benefit.
2008
brain metastasis; leiomyosarcoma; uterine metastasis.
01 Pubblicazione su rivista::01a Articolo in rivista
Uterine leiomyosarcoma metastatic to the brain: case report / Melone, ANGELINA GRAZIELLA; D'Elia, Alessandro; Brogna, Christian; Salvati, Maurizio. - In: TUMORI. - ISSN 2038-2529. - STAMPA. - 94:6(2008), pp. 856-860.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/499243
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