Idiopathic focal hand dystonia (FHD) arises from abnormal plasticity in the primary motor cortex (M1) possibly reflecting abnormal sensori-motor integration processes. In this transcranial magnetic stimulation (TMS) study in FHD, we evaluated changes in motor evoked potentials (MEPs) after intermittent theta burst stimulation (iTBS) and paired associative stimulation (PAS), techniques that elicit different forms of experimentally-induced long-term potentiation (LTP)-like plasticity in M1. We also examined behaviorally-induced LTP-like plasticity as reflected by early motor learning of a simple motor task. We studied 14 patients with FHD and 14 healthy subjects. MEPs were recorded before and after iTBS and PAS at the 25ms interstimulus interval (PAS25) in separate sessions. Subjects did a simple motor task entailing repetitive index finger abductions. To measure early motor learning we tested practice-related improvement in peak velocity and peak acceleration. In FHD patients iTBS failed to elicit the expected MEP changes and PAS25 induced abnormally increased MEPs in target and non-target muscles. In the experiment testing early motor learning, patients lacked the expected practice-related changes in kinematic variables. In FHD, the degree of early motor learning correlated with patients' clinical features. We conclude that experimentally-induced (iTBS and PAS) and behaviorally-induced LTP-like plasticity are both altered in FHD. © 2012 Elsevier Inc.

Abnormal experimentally- and behaviorally-induced LTP-like plasticity in focal hand dystonia / Belvisi, Daniele; Suppa, Antonio; Marsili, Luca; DI STASIO, Flavio; Ahmad Khandker, Parvez; Rocco, Agostino; Fabbrini, Giovanni; Berardelli, Alfredo. - In: EXPERIMENTAL NEUROLOGY. - ISSN 0014-4886. - 240:1(2013), pp. 64-74. [10.1016/j.expneurol.2012.11.003]

Abnormal experimentally- and behaviorally-induced LTP-like plasticity in focal hand dystonia

BELVISI, DANIELE;SUPPA, ANTONIO;MARSILI, LUCA;DI STASIO, FLAVIO;FABBRINI, Giovanni;BERARDELLI, Alfredo
2013

Abstract

Idiopathic focal hand dystonia (FHD) arises from abnormal plasticity in the primary motor cortex (M1) possibly reflecting abnormal sensori-motor integration processes. In this transcranial magnetic stimulation (TMS) study in FHD, we evaluated changes in motor evoked potentials (MEPs) after intermittent theta burst stimulation (iTBS) and paired associative stimulation (PAS), techniques that elicit different forms of experimentally-induced long-term potentiation (LTP)-like plasticity in M1. We also examined behaviorally-induced LTP-like plasticity as reflected by early motor learning of a simple motor task. We studied 14 patients with FHD and 14 healthy subjects. MEPs were recorded before and after iTBS and PAS at the 25ms interstimulus interval (PAS25) in separate sessions. Subjects did a simple motor task entailing repetitive index finger abductions. To measure early motor learning we tested practice-related improvement in peak velocity and peak acceleration. In FHD patients iTBS failed to elicit the expected MEP changes and PAS25 induced abnormally increased MEPs in target and non-target muscles. In the experiment testing early motor learning, patients lacked the expected practice-related changes in kinematic variables. In FHD, the degree of early motor learning correlated with patients' clinical features. We conclude that experimentally-induced (iTBS and PAS) and behaviorally-induced LTP-like plasticity are both altered in FHD. © 2012 Elsevier Inc.
2013
dystonia; tms; primary motor cortex; early motor learning; plasticity
01 Pubblicazione su rivista::01a Articolo in rivista
Abnormal experimentally- and behaviorally-induced LTP-like plasticity in focal hand dystonia / Belvisi, Daniele; Suppa, Antonio; Marsili, Luca; DI STASIO, Flavio; Ahmad Khandker, Parvez; Rocco, Agostino; Fabbrini, Giovanni; Berardelli, Alfredo. - In: EXPERIMENTAL NEUROLOGY. - ISSN 0014-4886. - 240:1(2013), pp. 64-74. [10.1016/j.expneurol.2012.11.003]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/498889
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 14
  • Scopus 43
  • ???jsp.display-item.citation.isi??? 38
social impact