BACKGROUND: The aim of this retrospective, multi-center study was to compare high- versus standard-dose lenograstim after chemotherapy in collecting target dose of CD34+ peripheral blood progenitor cells (PBPCs) in adult candidates for autologous transplant STUDY DESIGN AND METHODS: A total of 166 consecutive patients (28 acute leukemias [ALs], 77 lymphomas, 61 multiple myeloma [MM]) underwent 182 mobilization procedures Only the first were analyzed The CD34+ cell target was at least 2 x 10(6), 4 x 10(6), and 8 x 10(6)/kg and lenograstim started on days +19, +1, and +5 from the end of chemotherapy for AL, lymphomas, and MM, respectively Eighty-seven and 79 patients, respectively, received 5 and 10 mu g/kg/day lenograstim subcutaneously (sc) An analysis to evaluate factors predicting satisfactory procedures and outcome of transplants performed with first-mobilization-procedure PBPCs was conducted Most patients received 6 mg of pegfilgrastim or 5 mu g/kg/day lenograstim sc after transplant RESULTS: In multivariate analysis, high-dose lenograstim (p = 0 053) in MM and male sex (p = 0 028) were positive predictive factors for reaching cell target Fludarabine negatively influenced stimulation length (p = 0 002). Apheresis, CD34+ cells mobilized and collected, blood volume processed, side effects, transplants performed, and engraftment time were similar between lenograstim cohorts. Pegfilgrastim versus lenograstim delayed platelet (PLT) recovery times (13 days vs 11 days, p = 0 036) CONCLUSIONS: High-dose lenograstim more efficiently mobilized MM patients requiring the highest PBPC target but did not influence transplants performed and engraftment time Male patients mobilized more efficiently Fludarabine negatively influenced stimulation length Finally, pegfilgrastim seems to delay PLT recovery
Standard- versus high-dose lenograstim in adults with hematologic malignancies for peripheral blood progenitor cell mobilization / Romeo, A.; Chierichini, A.; Spagnoli, Alessandra; Vittori, M.; Vacca, M.; Gozzer, M.; Spadea, A.; Anaclerico, B.; Dessanti, M. l.; D'Andrea, M.; Toglia, G.; Annino, L.; Petti, M. c.; Mengarelli, A.; Arcese, W.. - In: TRANSFUSION. - ISSN 0041-1132. - 50:11(2010), pp. 2432-2446. [10.1111/j.1537-2995.2010.02723.x]
Standard- versus high-dose lenograstim in adults with hematologic malignancies for peripheral blood progenitor cell mobilization
SPAGNOLI, ALESSANDRA;M. c. Petti;
2010
Abstract
BACKGROUND: The aim of this retrospective, multi-center study was to compare high- versus standard-dose lenograstim after chemotherapy in collecting target dose of CD34+ peripheral blood progenitor cells (PBPCs) in adult candidates for autologous transplant STUDY DESIGN AND METHODS: A total of 166 consecutive patients (28 acute leukemias [ALs], 77 lymphomas, 61 multiple myeloma [MM]) underwent 182 mobilization procedures Only the first were analyzed The CD34+ cell target was at least 2 x 10(6), 4 x 10(6), and 8 x 10(6)/kg and lenograstim started on days +19, +1, and +5 from the end of chemotherapy for AL, lymphomas, and MM, respectively Eighty-seven and 79 patients, respectively, received 5 and 10 mu g/kg/day lenograstim subcutaneously (sc) An analysis to evaluate factors predicting satisfactory procedures and outcome of transplants performed with first-mobilization-procedure PBPCs was conducted Most patients received 6 mg of pegfilgrastim or 5 mu g/kg/day lenograstim sc after transplant RESULTS: In multivariate analysis, high-dose lenograstim (p = 0 053) in MM and male sex (p = 0 028) were positive predictive factors for reaching cell target Fludarabine negatively influenced stimulation length (p = 0 002). Apheresis, CD34+ cells mobilized and collected, blood volume processed, side effects, transplants performed, and engraftment time were similar between lenograstim cohorts. Pegfilgrastim versus lenograstim delayed platelet (PLT) recovery times (13 days vs 11 days, p = 0 036) CONCLUSIONS: High-dose lenograstim more efficiently mobilized MM patients requiring the highest PBPC target but did not influence transplants performed and engraftment time Male patients mobilized more efficiently Fludarabine negatively influenced stimulation length Finally, pegfilgrastim seems to delay PLT recoveryI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
