We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 x 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 x 10(-15); OR = 1.50).

Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk / Nick, Orr; Alina, Lemnrau; Rosie, Cooke; Olivia, Fletcher; Katarzyna, Tomczyk; Michael, Jones; Nichola, Johnson; Christopher J., Lord; Costas, Mitsopoulos; Marketa, Zvelebil; Simon S., Mcdade; Gemma, Buck; Christine, Blancher; Alison H., Trainer; Paul A., James; Stig E., Bojesen; Susanne, Bokmand; Heli, Nevanlinna; Johanna, Mattson; Eitan, Friedman; Yael, Laitman; Domenico, Palli; Giovanna, Masala; Ines, Zanna; Ottini, Laura; Giannini, Giuseppe; Antoinette, Hollestelle; A. m. w., Van Den Ouweland; Srdjan, Novakovic; Mateja, Krajc; Manuela Gago, Dominguez; Jose Esteban, Castelao; Hakan, Olsson; Ingrid, Hedenfalk; Douglas F., Easton; Paul D. p., Pharoah; Alison M., Dunning; D., Timothy Bishop; Susan L., Neuhausen; Linda, Steele; Richard S., Houlston; Montserrat Garcia, Closas; Alan, Ashworth; Anthony J., Swerdlow. - In: NATURE GENETICS. - ISSN 1061-4036. - 44:11(2012), pp. 1182-1184. [10.1038/ng.2417]

Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

OTTINI, LAURA;GIANNINI, Giuseppe;
2012

Abstract

We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 x 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 x 10(-15); OR = 1.50).
2012
01 Pubblicazione su rivista::01a Articolo in rivista
Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk / Nick, Orr; Alina, Lemnrau; Rosie, Cooke; Olivia, Fletcher; Katarzyna, Tomczyk; Michael, Jones; Nichola, Johnson; Christopher J., Lord; Costas, Mitsopoulos; Marketa, Zvelebil; Simon S., Mcdade; Gemma, Buck; Christine, Blancher; Alison H., Trainer; Paul A., James; Stig E., Bojesen; Susanne, Bokmand; Heli, Nevanlinna; Johanna, Mattson; Eitan, Friedman; Yael, Laitman; Domenico, Palli; Giovanna, Masala; Ines, Zanna; Ottini, Laura; Giannini, Giuseppe; Antoinette, Hollestelle; A. m. w., Van Den Ouweland; Srdjan, Novakovic; Mateja, Krajc; Manuela Gago, Dominguez; Jose Esteban, Castelao; Hakan, Olsson; Ingrid, Hedenfalk; Douglas F., Easton; Paul D. p., Pharoah; Alison M., Dunning; D., Timothy Bishop; Susan L., Neuhausen; Linda, Steele; Richard S., Houlston; Montserrat Garcia, Closas; Alan, Ashworth; Anthony J., Swerdlow. - In: NATURE GENETICS. - ISSN 1061-4036. - 44:11(2012), pp. 1182-1184. [10.1038/ng.2417]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/496906
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