The circadian (about 24-hr) oscillating function of the renin-angiotensin-aldosterone system (RAAS) was investigated as a function of age in clinically healthy participants and in essential hypertensive patients. A peculiar age-related decline in the RAAS circadian mesor (rhythm-adjusted mean) and amplitude (variability from mesor) was found in the essential hypertensive patients. This finding suggests a nonphysiologic evolution in the tonic (24-hr mean level) as well as phasic (oscillating amplitude) circadian activity of the RAAS with increasing age. A relative hyperreninemic aldosteronism characterized the aged essential hypertensive patients.
The gerontological decline of the renin-aldosterone system: a chronobiological approach extended to essential hypertension / Cugini, Pietro; G., Murano; Lucia, Piernatale; Letizia, Claudio; D., Scavo; F., Halberg; A., Schramm. - In: JOURNAL OF GERONTOLOGY. - ISSN 0022-1422. - STAMPA. - 42:5(1987), pp. 461-465.
The gerontological decline of the renin-aldosterone system: a chronobiological approach extended to essential hypertension.
CUGINI, Pietro;LUCIA, Piernatale;LETIZIA, Claudio;
1987
Abstract
The circadian (about 24-hr) oscillating function of the renin-angiotensin-aldosterone system (RAAS) was investigated as a function of age in clinically healthy participants and in essential hypertensive patients. A peculiar age-related decline in the RAAS circadian mesor (rhythm-adjusted mean) and amplitude (variability from mesor) was found in the essential hypertensive patients. This finding suggests a nonphysiologic evolution in the tonic (24-hr mean level) as well as phasic (oscillating amplitude) circadian activity of the RAAS with increasing age. A relative hyperreninemic aldosteronism characterized the aged essential hypertensive patients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
