Four fluoroquinolones (norfloxacin, ciprofloxacin, ofloxacin and pefloxacin) were compared with nalidixic acid for their inhibitory effect on conjugal plasmid transfer. The inhibition was observed in mating experiments using various combinations of drugs at subinhibitory concentrations and 3 different plasmids in the E.coli K12 genetic background.Fluoroquinolones inhibited plasmid transfer to a greater extent than nalidixic acid. Ofloxacin and Pefloxacin were consistently the most active agents, causing 90 to 100% inhibition of plasmid transfer in all mating system studied.
Inhibition of Plasmid Conjugation by Some Recently Synthetized 4-Quinolone Compounds / Scazzocchio, Francesca; Selan, Laura; Oliva, B.; Schippa, S.; Renzini, L. C. e. l. l. i. n. i. G.. - In: CHEMIOTERAPIA. - ISSN 0392-906X. - STAMPA. - 7 (5):(1988), pp. 295-297.
Inhibition of Plasmid Conjugation by Some Recently Synthetized 4-Quinolone Compounds
SCAZZOCCHIO, Francesca;SELAN, Laura;S. Schippa;
1988
Abstract
Four fluoroquinolones (norfloxacin, ciprofloxacin, ofloxacin and pefloxacin) were compared with nalidixic acid for their inhibitory effect on conjugal plasmid transfer. The inhibition was observed in mating experiments using various combinations of drugs at subinhibitory concentrations and 3 different plasmids in the E.coli K12 genetic background.Fluoroquinolones inhibited plasmid transfer to a greater extent than nalidixic acid. Ofloxacin and Pefloxacin were consistently the most active agents, causing 90 to 100% inhibition of plasmid transfer in all mating system studied.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
