Biomaterial-associated infections have an enormous impact in terms of morbidity of the patients and costs to national health systems. Perioperative antibiotics and aseptic procedures have not proved sufficient to eradicate the occurrence of this type of infections which often lead to devastating effects. Adjunctive strategies for preventing the establishment of infections are increasingly being centered on the development of new biomaterials with anti-infective properties. The creation of new anti-infective biomaterials can be obtained by alternative approaches oriented to achieve either bacteria-repellent surfaces or bioactive surfaces expressing self-sterilizing properties when not even able to treat preexisting infections in the surrounding tissues. Here, we offer a short overview of the currently available in vitro methods that can be used to investigate and assess the performance of anti-infective biometerials, with special emphasis on those whose mechanism of action is based on bacteria-repellent surfaces.

An overview of the methodological approach to the in vitro study of anti-infective biomaterials / Davide, Campoccia; Ilaria, Cangini; Selan, Laura; Marco, Vercellino; Lucio, Montanaro; Livia, Visai; Carla Renata, Arciola. - In: INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS. - ISSN 0391-3988. - 35:10(2012), pp. 800-816. [10.5301/ijao.5000140]

An overview of the methodological approach to the in vitro study of anti-infective biomaterials

SELAN, Laura;
2012

Abstract

Biomaterial-associated infections have an enormous impact in terms of morbidity of the patients and costs to national health systems. Perioperative antibiotics and aseptic procedures have not proved sufficient to eradicate the occurrence of this type of infections which often lead to devastating effects. Adjunctive strategies for preventing the establishment of infections are increasingly being centered on the development of new biomaterials with anti-infective properties. The creation of new anti-infective biomaterials can be obtained by alternative approaches oriented to achieve either bacteria-repellent surfaces or bioactive surfaces expressing self-sterilizing properties when not even able to treat preexisting infections in the surrounding tissues. Here, we offer a short overview of the currently available in vitro methods that can be used to investigate and assess the performance of anti-infective biometerials, with special emphasis on those whose mechanism of action is based on bacteria-repellent surfaces.
2012
bacterial adhesion; biofilm; anti-infective biomaterials; implant infections
01 Pubblicazione su rivista::01a Articolo in rivista
An overview of the methodological approach to the in vitro study of anti-infective biomaterials / Davide, Campoccia; Ilaria, Cangini; Selan, Laura; Marco, Vercellino; Lucio, Montanaro; Livia, Visai; Carla Renata, Arciola. - In: INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS. - ISSN 0391-3988. - 35:10(2012), pp. 800-816. [10.5301/ijao.5000140]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/495598
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