Nalidixic acid and two recently synthetized 4-quinolones eliminated F'lac and R-plasmids from E. coli at concentrations of one half or one quarter of the minimum inhibitory concentration (MIC). Two of the three plasmids tested were cured by all derivatives, although with different frequencies. Pefloxacin was the most effective compound compared with the other quinolones and nalidixic acid the least active.
PLASMID CURING BY SOME RECENTLY SYNTHETIZED 4-QUINOLONE COMPOUNDS / Selan, Laura; Scazzocchio, Francesca; Oliva, B.; Schippa, S.; Allocati, N.; Renzini, Giulio. - In: CHEMIOTERAPIA. - ISSN 0392-906X. - STAMPA. - 7:5(1988), pp. 292-294.
PLASMID CURING BY SOME RECENTLY SYNTHETIZED 4-QUINOLONE COMPOUNDS
SELAN, Laura;SCAZZOCCHIO, Francesca;S. Schippa;RENZINI, Giulio
1988
Abstract
Nalidixic acid and two recently synthetized 4-quinolones eliminated F'lac and R-plasmids from E. coli at concentrations of one half or one quarter of the minimum inhibitory concentration (MIC). Two of the three plasmids tested were cured by all derivatives, although with different frequencies. Pefloxacin was the most effective compound compared with the other quinolones and nalidixic acid the least active.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
