Impulsiveness neurobiological substrate in borderline personality disorder

Tendency to answer to frustrations with "acting out" in Borderline personality disorder suggests a difficult symbolising process. Neurobiological studies evidence a malfunctioning of frontal, prefrontal and limbic areas probably neurobiological substrate of impulsiveness. After complete psychological screening and SCIDII interview, by a video emotional activation paradigm, standard-SPECT analysis recorded cerebral activity of 3 borderline personality disorder patients and of a control subject. In borderline patients, but not in control subject, limbic areas, frontal and prefrontal cortex activation was present perhaps to show a cognitive activity put in action in order to manage the strong emotion triggered by video.