Abstract. Age-related macular degeneration (AMD) is the leading cause of impaired vision and blindness in the aging population. The aims of our studies were to identify qualitative and quantitative alterations in mitochondria in human retinal pigment epithelium (RPE) from AMD patients and controls and to test the protective effects of pigment epithelium-derived factor (PEDF), a known neurotrophic and antiangiogenic substance, against neurotrophic keratouveitis. Histopathological alterations were studied by means of morphometry, light and electron microscopy. Unexpectedly, morphometric data showed that the RPE alterations noted in AMD may also develop in normal aging, 10-15 years later than appearing in AMD patients. Reduced tear secretion, corneal ulceration and leukocytic infiltration were found in capsaicin (CAP)-treated rats, but this effect was significantly attenuated by PEDF. These findings suggest that PEDF accelerated the recovery of tear secretion and also prevented neurotrophic keratouveitis and vitreoretinal inflammation. PEDF may have a clinical appli

Retinal pigment epithelium, age-related macular degeneration and neurotrophic keratouveitis / Bianchi, Enrica; Scarinci, Fabio; Ripandelli, G; Feher, J; Pacella, Elena; Magliulo, Giuseppe; Gabrieli, Cb; Plateroti, Rocco; Plateroti, Pasquale; Mignini, F; Artico, Marco. - In: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. - ISSN 1107-3756. - STAMPA. - 1:31(2013), pp. 232-242. [10.3892/ijmm.2012.1164]

Retinal pigment epithelium, age-related macular degeneration and neurotrophic keratouveitis.

BIANCHI, ENRICA;SCARINCI, FABIO;PACELLA, Elena;MAGLIULO, Giuseppe;PLATEROTI, Rocco;PLATEROTI, PASQUALE;ARTICO, Marco
2013

Abstract

Abstract. Age-related macular degeneration (AMD) is the leading cause of impaired vision and blindness in the aging population. The aims of our studies were to identify qualitative and quantitative alterations in mitochondria in human retinal pigment epithelium (RPE) from AMD patients and controls and to test the protective effects of pigment epithelium-derived factor (PEDF), a known neurotrophic and antiangiogenic substance, against neurotrophic keratouveitis. Histopathological alterations were studied by means of morphometry, light and electron microscopy. Unexpectedly, morphometric data showed that the RPE alterations noted in AMD may also develop in normal aging, 10-15 years later than appearing in AMD patients. Reduced tear secretion, corneal ulceration and leukocytic infiltration were found in capsaicin (CAP)-treated rats, but this effect was significantly attenuated by PEDF. These findings suggest that PEDF accelerated the recovery of tear secretion and also prevented neurotrophic keratouveitis and vitreoretinal inflammation. PEDF may have a clinical appli
2013
retinal pigment epithelium; mitochondria; lipofuscin; peroxisomes; age-related macular degeneration; pigment epitheliumderived factor; light microscopy; electron microscopy; morphometry
01 Pubblicazione su rivista::01a Articolo in rivista
Retinal pigment epithelium, age-related macular degeneration and neurotrophic keratouveitis / Bianchi, Enrica; Scarinci, Fabio; Ripandelli, G; Feher, J; Pacella, Elena; Magliulo, Giuseppe; Gabrieli, Cb; Plateroti, Rocco; Plateroti, Pasquale; Mignini, F; Artico, Marco. - In: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. - ISSN 1107-3756. - STAMPA. - 1:31(2013), pp. 232-242. [10.3892/ijmm.2012.1164]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/493017
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