The asymmetric addition of malonates to in situ generated N-formylimines of aromatic aldehydes was achieved under phase-transfer catalysis using Cinchona alkaloids-derived quaternary ammonium salts. The resulting β- formamidomalonates have been efficiently converted into β-aryl-β- isocyano esters. Their utility in the multicomponent Ugi reaction with chiral cyclic imines has been demonstrated. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Organocatalytic asymmetric synthesis of β-aryl-β-isocyano esters / Fabio, Morana; Andrea, Basso; Bella, Marco; Renata, Riva; Luca, Banfi. - In: ADVANCED SYNTHESIS & CATALYSIS. - ISSN 1615-4150. - STAMPA. - 354:11-12(2012), pp. 2199-2210. [10.1002/adsc.201200140]
Organocatalytic asymmetric synthesis of β-aryl-β-isocyano esters
BELLA, Marco;
2012
Abstract
The asymmetric addition of malonates to in situ generated N-formylimines of aromatic aldehydes was achieved under phase-transfer catalysis using Cinchona alkaloids-derived quaternary ammonium salts. The resulting β- formamidomalonates have been efficiently converted into β-aryl-β- isocyano esters. Their utility in the multicomponent Ugi reaction with chiral cyclic imines has been demonstrated. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
