We studied the long-term effects of a postnatal choline supplementation (from birth till weaning) in the truncated MeCP2-308 mouse model of Rett syndrome. Adult male mutant hemizygous (hz) mice showed a reduction of locomotor activity compared to wild type (wt) littermates. Early choline treatment restored wt-like locomotor activity levels in hz mice. Reduced striatal choline acetyl transferase (ChAT) activity and decreased levels of cortical mRNA NGF were found in hz mice. Choline supplementation increased striatal ChAT activity and also enhanced NGF and BDNF expression in cortical and hippocampal regions. As a whole, postnatal choline supplementation attenuates some of the behavioural and neurobiological abnormalities of the Mecp2-308 phenotype. © 2011 Elsevier B.V.

Cholinergic hypofunction in MeCP2-308 mice: Beneficial neurobehavioural effects of neonatal choline supplementation / Laura, Ricceri; Bianca De, Filippis; Fuso, Andrea; Giovanni, Laviola. - In: BEHAVIOURAL BRAIN RESEARCH. - ISSN 0166-4328. - 221:2(2011), pp. 623-629. [10.1016/j.bbr.2011.03.051]

Cholinergic hypofunction in MeCP2-308 mice: Beneficial neurobehavioural effects of neonatal choline supplementation

FUSO, ANDREA;
2011

Abstract

We studied the long-term effects of a postnatal choline supplementation (from birth till weaning) in the truncated MeCP2-308 mouse model of Rett syndrome. Adult male mutant hemizygous (hz) mice showed a reduction of locomotor activity compared to wild type (wt) littermates. Early choline treatment restored wt-like locomotor activity levels in hz mice. Reduced striatal choline acetyl transferase (ChAT) activity and decreased levels of cortical mRNA NGF were found in hz mice. Choline supplementation increased striatal ChAT activity and also enhanced NGF and BDNF expression in cortical and hippocampal regions. As a whole, postnatal choline supplementation attenuates some of the behavioural and neurobiological abnormalities of the Mecp2-308 phenotype. © 2011 Elsevier B.V.
2011
scopolamine; motor activity; diet therapy/metabolism/physiopathology/psychology; brain-derived neurotrophic factor; nutritional factors; pharmacology; mice; drug effects/physiology; mutant strains; cerebral cortex; methyl-cpg-binding protein 2; behavioural phenotyping; choline o-acetyltransferase; cholinergic system; corpus striatum; animal; animals; dietary supplements; metabolism; male; drug effects; exploratory behavior; genetics; cholinergic fibers; rett syndrome; drug effects/metabolism; administration /&/ dosage/pharmacology/therapeutic use; nerve growth factor; disease models; hippocampus; scopolamine hydrobromide; neurotrophines; choline
01 Pubblicazione su rivista::01a Articolo in rivista
Cholinergic hypofunction in MeCP2-308 mice: Beneficial neurobehavioural effects of neonatal choline supplementation / Laura, Ricceri; Bianca De, Filippis; Fuso, Andrea; Giovanni, Laviola. - In: BEHAVIOURAL BRAIN RESEARCH. - ISSN 0166-4328. - 221:2(2011), pp. 623-629. [10.1016/j.bbr.2011.03.051]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/492017
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