HIGH-RISK patients stili constitute a particular class of potential candidates for transplantation, because of the difficulties in preventing immunological complications, while avoiding the side effects of vigorous immunosuppressive therapy. In the last few years, different approaches have been used to manipulate the patient's immunoreactivity before and after transplantation. Among these, total lymphoid irradiation (TLI), based on the protocol of treatment of Hodgkin's disease, has been successfully used in experimental and clinical allografts.1"6 More recently, a new immunosuppressive drug, cyclosporine (CsA) with selective activity against immunocompetent cells, has made possible significant improvements in clinical graft survival. 7 Both therapeutic approaches have also shown
Combined Immunosuppressive Clinical Protocol: Experience With Total Lymphoid Irradiation Plus Cyclosporine / D., Alfani; G., Marinucci; E., Renna Molajoni; C., Monari; A., Capua; Berloco, Pasquale Bartolomeo; A., Famulari; Rossi, Massimo; R., Cortesini. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - STAMPA. - XVII ( suppl. 2):(1985), pp. 49-53.
Combined Immunosuppressive Clinical Protocol: Experience With Total Lymphoid Irradiation Plus Cyclosporine
BERLOCO, Pasquale Bartolomeo;ROSSI, MASSIMO;
1985
Abstract
HIGH-RISK patients stili constitute a particular class of potential candidates for transplantation, because of the difficulties in preventing immunological complications, while avoiding the side effects of vigorous immunosuppressive therapy. In the last few years, different approaches have been used to manipulate the patient's immunoreactivity before and after transplantation. Among these, total lymphoid irradiation (TLI), based on the protocol of treatment of Hodgkin's disease, has been successfully used in experimental and clinical allografts.1"6 More recently, a new immunosuppressive drug, cyclosporine (CsA) with selective activity against immunocompetent cells, has made possible significant improvements in clinical graft survival. 7 Both therapeutic approaches have also shownI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
