The first case of hypophosphatasia in adults reported in Italy (20th in the world) is described with remarks on the epidemiology, pathogenesis and therapeutic possibilities. The formation of renal and cholecystic calculi after long-term, intensive vitamin D and Calcium therapy indicates the limited capacity of pyrophosphate (PPi), even in large doses, to prevent the precipitation in man of calcium and phosphorus and the subsequent formation of ectopic calcifications.
[Ectopic calcifications in adult hypophosphatasia] / Frustaci, Andrea; N., Gentiloni; G., Coiana; F., Breccia. - In: MINERVA MEDICA. - ISSN 0026-4806. - STAMPA. - 74:27(1983), pp. 1651-1654.
[Ectopic calcifications in adult hypophosphatasia].
FRUSTACI, ANDREA;
1983
Abstract
The first case of hypophosphatasia in adults reported in Italy (20th in the world) is described with remarks on the epidemiology, pathogenesis and therapeutic possibilities. The formation of renal and cholecystic calculi after long-term, intensive vitamin D and Calcium therapy indicates the limited capacity of pyrophosphate (PPi), even in large doses, to prevent the precipitation in man of calcium and phosphorus and the subsequent formation of ectopic calcifications.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
