NK-1, NK-15 subsets and natural killer (NK) activity were studied in 13 patients, before undergoing renal transplantation and in the post-transplant period. Pretransplant there was a significant reduction of NK activity with a defect in Vmax capacity in all patients. NK-1+ and NK-15+ cell number was normal or slightly increased in all subjects. Post-transplant evaluation under cyclosporine immunosuppression showed a quantitative reduction in NK cells while no changes in NK activity and killing activity have been seen. We conclude that in spite of a numerical decrease, NK activity was not affected by cyclosporine treatment.
MONITORING OF NK-1 AND NK-15 SUBSETS AND NATURAL-KILLER ACTIVITY IN KIDNEY-TRANSPLANT RECIPIENTS RECEIVING CYCLOSPORINE / E. R., Molajoni; Barnaba, Vincenzo; Bachetoni, A.; Levrero, Massimo; P., Cinti; Rossi, Massimo; D., Alfani; R., Cortesini. - In: PROCEEDINGS OF THE EUROPEAN DIALYSIS AND TRANSPLANT ASSOCIATION. - ISSN 0959-9800. - STAMPA. - 21:(1985), pp. 1042-1046.
MONITORING OF NK-1 AND NK-15 SUBSETS AND NATURAL-KILLER ACTIVITY IN KIDNEY-TRANSPLANT RECIPIENTS RECEIVING CYCLOSPORINE
BARNABA, Vincenzo;A. Bachetoni;LEVRERO, Massimo;ROSSI, MASSIMO;
1985
Abstract
NK-1, NK-15 subsets and natural killer (NK) activity were studied in 13 patients, before undergoing renal transplantation and in the post-transplant period. Pretransplant there was a significant reduction of NK activity with a defect in Vmax capacity in all patients. NK-1+ and NK-15+ cell number was normal or slightly increased in all subjects. Post-transplant evaluation under cyclosporine immunosuppression showed a quantitative reduction in NK cells while no changes in NK activity and killing activity have been seen. We conclude that in spite of a numerical decrease, NK activity was not affected by cyclosporine treatment.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
