A direct semipreparative HPLC enantioseparation of two chiral thiazolidinone derivatives having cyclooxygenase-2 inhibition activity was performed on the Chiralpak IA chiral stationary phase. Semipreparative amounts of enantiopure forms were collected using acetonitrile-ethanol-trifluoroacetic acid mixtures as mobile phase. The absolute configuration of both compounds was unequivocally established by single-crystal X-ray diffraction method and correlated to the chiroptical properties of isolated enantiomers. Chirality 22:56-62, 2010. (C) 2009 Wiley-Liss, Inc.
Semipreparative HPLC Enantioseparation, Chiroptical Properties, and Absolute Configuration of Two Novel Cyclooxygenase-2 Inhibitors / Roberto, Cirilli; Stefano, Fiore; Francesco La, Torre; Elias, Maccioni; Secci, Daniela; Maria Luisa, Sanna; Cristina, Faggi. - In: CHIRALITY. - ISSN 0899-0042. - 22:1(2010), pp. 56-62. [10.1002/chir.20705]
Semipreparative HPLC Enantioseparation, Chiroptical Properties, and Absolute Configuration of Two Novel Cyclooxygenase-2 Inhibitors
SECCI, DANIELA;
2010
Abstract
A direct semipreparative HPLC enantioseparation of two chiral thiazolidinone derivatives having cyclooxygenase-2 inhibition activity was performed on the Chiralpak IA chiral stationary phase. Semipreparative amounts of enantiopure forms were collected using acetonitrile-ethanol-trifluoroacetic acid mixtures as mobile phase. The absolute configuration of both compounds was unequivocally established by single-crystal X-ray diffraction method and correlated to the chiroptical properties of isolated enantiomers. Chirality 22:56-62, 2010. (C) 2009 Wiley-Liss, Inc.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
