Objective: Acute promyelocytic leukemia (APL) comprises approximately 10% of the acute myeloblastíc leuketnias (AML). Extiameduilàry inuoluements at presentdtion or relapse is an infrequent complication of AML and extremely uficotnnlon in APL. Material and Method: The case report of a 22-years-old female uith APL who relapsed with extramedullary disease and a reuiew of the líterature are presented. Results: The patient with cytogenetically and molecularly confirrued APL deueloped extramedullary relapse in middle ear and externai auditory canal after tredtment with chemotberapy. Blood picture, bone ruarrolt) aspirdte and lumbar puncture were negatiue for leukaemic cells. A reuiew of the literature reuealed only eleuen cases of APL complicated by otological dísease. tion if otouhea is present (relapse in tymp(tnic cauity with iy*pant, membyane perforation) and/or CT scan (otological disease uith noimal eardrum). The aboue to reduce exploratiue myringotomy in pat.ie
Remissione Di Leucemia Acuta Promielocitica Complicata Da Patologia Otologica / Fusconi, Massimo; Magliulo, Giuseppe; Pulice, G.; DE VINCENTIIS, Marco. - In: VALSALVA. - ISSN 0042-2371. - STAMPA. - LXXVII(4):4 ott-dic(2001), pp. 169-176.
Remissione Di Leucemia Acuta Promielocitica Complicata Da Patologia Otologica
FUSCONI, Massimo;MAGLIULO, Giuseppe;DE VINCENTIIS, Marco
2001
Abstract
Objective: Acute promyelocytic leukemia (APL) comprises approximately 10% of the acute myeloblastíc leuketnias (AML). Extiameduilàry inuoluements at presentdtion or relapse is an infrequent complication of AML and extremely uficotnnlon in APL. Material and Method: The case report of a 22-years-old female uith APL who relapsed with extramedullary disease and a reuiew of the líterature are presented. Results: The patient with cytogenetically and molecularly confirrued APL deueloped extramedullary relapse in middle ear and externai auditory canal after tredtment with chemotberapy. Blood picture, bone ruarrolt) aspirdte and lumbar puncture were negatiue for leukaemic cells. A reuiew of the literature reuealed only eleuen cases of APL complicated by otological dísease. tion if otouhea is present (relapse in tymp(tnic cauity with iy*pant, membyane perforation) and/or CT scan (otological disease uith noimal eardrum). The aboue to reduce exploratiue myringotomy in pat.ieI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
