Response fluctuations in motor function, complicating long-term dopaminomimetic therapy of Parkinson's disease, may extend to the cognitive realm. To evaluate the effect of levodopa treatment both on attention as well as acquisition and retrieval of memory tasks, parkinsonian patients were examined neuropsychologically both while medicated with levodopa/carbidopa ("on") and when the medication's antiparkinsonian effect had worn off ("off"). Significant cognitive differences emerged only on the delayed recall of complex verbal materials, where patients when "on" performed better compared with their "off" state. Comparison of change scores across states (administration or withholding of levodopa/carbidopa between acquisition and retrieval, "off" to "on" or "on" to "off"), revealed no substantial differences as a function of dopaminomimetic therapy. These results support the view that slight changes in cognition are associated with dopaminomimetic therapy of Parkinson's disease, but that these changes may be task-specific.

Dopamine and memory function in Parkinson's disease / Erich, Mohr; Fabbrini, Giovanni; Jill, Williams; Jerry, Schlegel; Christiane, Cox; Paul, Fedio; Thomas N., Chase. - In: MOVEMENT DISORDERS. - ISSN 0885-3185. - 4:2(1989), pp. 113-120. [10.1002/mds.870040202]

Dopamine and memory function in Parkinson's disease.

FABBRINI, Giovanni;
1989

Abstract

Response fluctuations in motor function, complicating long-term dopaminomimetic therapy of Parkinson's disease, may extend to the cognitive realm. To evaluate the effect of levodopa treatment both on attention as well as acquisition and retrieval of memory tasks, parkinsonian patients were examined neuropsychologically both while medicated with levodopa/carbidopa ("on") and when the medication's antiparkinsonian effect had worn off ("off"). Significant cognitive differences emerged only on the delayed recall of complex verbal materials, where patients when "on" performed better compared with their "off" state. Comparison of change scores across states (administration or withholding of levodopa/carbidopa between acquisition and retrieval, "off" to "on" or "on" to "off"), revealed no substantial differences as a function of dopaminomimetic therapy. These results support the view that slight changes in cognition are associated with dopaminomimetic therapy of Parkinson's disease, but that these changes may be task-specific.
1989
01 Pubblicazione su rivista::01a Articolo in rivista
Dopamine and memory function in Parkinson's disease / Erich, Mohr; Fabbrini, Giovanni; Jill, Williams; Jerry, Schlegel; Christiane, Cox; Paul, Fedio; Thomas N., Chase. - In: MOVEMENT DISORDERS. - ISSN 0885-3185. - 4:2(1989), pp. 113-120. [10.1002/mds.870040202]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/488583
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