Theinteractionsbetweenintestinalmicrobiota,immunesystem,andpathogensdescribethehumangutasacomplexecosystem,whereallcomponentsplayarelevantroleinmodulatingeachotherandinthemaintenanceofhomeostasis.Thebalanceamongthegutmicrobiotaandthehumanbodyappeartobecrucialforhealthmaintenance.Intestinalparasites,bothprotozoansandhelminths,interactwiththemicrobialcommunitymodifyingthebalancebetweenhostandcommensalmicrobiota.Ontheotherhand,gutmicrobiotarepresentsarelevantfactorthatmaystronglyinterferewiththepathophysiologyoftheinfections.Inadditiontothefunctionthatgutcommensalmicrobiotamayhaveintheprocessesthatdeterminethesurvivalandtheoutcomeofmanyparasiticinfections,includingtheproductionofnutritivemacromolecules,alsoprobioticscanplayanimportantroleinreducingthepathogenicityofmanyparasites.Onthesebases,thereisagrowinginterestinexplainingtherationaleonthepossibleinteractionsbetweenthemicrobiota,immuneresponse,inflammatoryprocesses,andintestinalparasites.
Interactions between parasites and microbial communities in the human gut / Federica, Berrilli; David Di, Cave; Cavallero, Serena; D'Amelio, Stefano. - In: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. - ISSN 2235-2988. - ELETTRONICO. - 2:(2012), pp. 1-6. [10.3389/fcimb.2012.00141]
Interactions between parasites and microbial communities in the human gut
CAVALLERO, Serena;D'AMELIO, Stefano
2012
Abstract
Theinteractionsbetweenintestinalmicrobiota,immunesystem,andpathogensdescribethehumangutasacomplexecosystem,whereallcomponentsplayarelevantroleinmodulatingeachotherandinthemaintenanceofhomeostasis.Thebalanceamongthegutmicrobiotaandthehumanbodyappeartobecrucialforhealthmaintenance.Intestinalparasites,bothprotozoansandhelminths,interactwiththemicrobialcommunitymodifyingthebalancebetweenhostandcommensalmicrobiota.Ontheotherhand,gutmicrobiotarepresentsarelevantfactorthatmaystronglyinterferewiththepathophysiologyoftheinfections.Inadditiontothefunctionthatgutcommensalmicrobiotamayhaveintheprocessesthatdeterminethesurvivalandtheoutcomeofmanyparasiticinfections,includingtheproductionofnutritivemacromolecules,alsoprobioticscanplayanimportantroleinreducingthepathogenicityofmanyparasites.Onthesebases,thereisagrowinginterestinexplainingtherationaleonthepossibleinteractionsbetweenthemicrobiota,immuneresponse,inflammatoryprocesses,andintestinalparasites.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
