Pathoadaptive mutations are evolutionary events leading to the silencing of specific anti-virulence loci. This reshapes the core genome of a novel pathogen, adapts it to the host and boosts its harmful potential. A paradigmatic case is the emergence of Shigella, the causative agent of bacillary dysentery, from its innocuous Escherichia coli ancestor. Here we summarize current views on how pathoadaptation has allowed Shigella to progressively increase its virulence. In this context, modification of the polyamine pattern emerges as a crucial step towards full expression of the virulence program in Shigella. (c) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Shedding of genes that interfere with the pathogenic lifestyle: the Shigella model / Prosseda, Gianni; DI MARTINO, MARIA LETIZIA; Campilongo, Rosaria; Fioravanti, R.; Micheli, G.; Casalino, M.; Colonna, Bianca. - In: RESEARCH IN MICROBIOLOGY. - ISSN 0923-2508. - STAMPA. - 163:6-7(2012), pp. 399-406. [10.1016/j.resmic.2012.07.004]
Shedding of genes that interfere with the pathogenic lifestyle: the Shigella model
PROSSEDA, Gianni;DI MARTINO, MARIA LETIZIA;CAMPILONGO, ROSARIA;COLONNA, Bianca
2012
Abstract
Pathoadaptive mutations are evolutionary events leading to the silencing of specific anti-virulence loci. This reshapes the core genome of a novel pathogen, adapts it to the host and boosts its harmful potential. A paradigmatic case is the emergence of Shigella, the causative agent of bacillary dysentery, from its innocuous Escherichia coli ancestor. Here we summarize current views on how pathoadaptation has allowed Shigella to progressively increase its virulence. In this context, modification of the polyamine pattern emerges as a crucial step towards full expression of the virulence program in Shigella. (c) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.