Pathoadaptive mutations are evolutionary events leading to the silencing of specific anti-virulence loci. This reshapes the core genome of a novel pathogen, adapts it to the host and boosts its harmful potential. A paradigmatic case is the emergence of Shigella, the causative agent of bacillary dysentery, from its innocuous Escherichia coli ancestor. Here we summarize current views on how pathoadaptation has allowed Shigella to progressively increase its virulence. In this context, modification of the polyamine pattern emerges as a crucial step towards full expression of the virulence program in Shigella. (c) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Shedding of genes that interfere with the pathogenic lifestyle: the Shigella model / Prosseda, Gianni; DI MARTINO, MARIA LETIZIA; Campilongo, Rosaria; Fioravanti, R.; Micheli, G.; Casalino, M.; Colonna, Bianca. - In: RESEARCH IN MICROBIOLOGY. - ISSN 0923-2508. - STAMPA. - 163:6-7(2012), pp. 399-406. [10.1016/j.resmic.2012.07.004]

Shedding of genes that interfere with the pathogenic lifestyle: the Shigella model

PROSSEDA, Gianni;DI MARTINO, MARIA LETIZIA;CAMPILONGO, ROSARIA;COLONNA, Bianca
2012

Abstract

Pathoadaptive mutations are evolutionary events leading to the silencing of specific anti-virulence loci. This reshapes the core genome of a novel pathogen, adapts it to the host and boosts its harmful potential. A paradigmatic case is the emergence of Shigella, the causative agent of bacillary dysentery, from its innocuous Escherichia coli ancestor. Here we summarize current views on how pathoadaptation has allowed Shigella to progressively increase its virulence. In this context, modification of the polyamine pattern emerges as a crucial step towards full expression of the virulence program in Shigella. (c) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
2012
bacterial evolution
01 Pubblicazione su rivista::01a Articolo in rivista
Shedding of genes that interfere with the pathogenic lifestyle: the Shigella model / Prosseda, Gianni; DI MARTINO, MARIA LETIZIA; Campilongo, Rosaria; Fioravanti, R.; Micheli, G.; Casalino, M.; Colonna, Bianca. - In: RESEARCH IN MICROBIOLOGY. - ISSN 0923-2508. - STAMPA. - 163:6-7(2012), pp. 399-406. [10.1016/j.resmic.2012.07.004]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/486642
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 24
  • Scopus 36
  • ???jsp.display-item.citation.isi??? 34
social impact