Genomic structure and transcriptional regulation of Che-1, a novel partner of Rb

Lucia, Monaco; Passananti, C.; Fanciulli, M.

doi:10.1016/s0378-1119(03)00834-5

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We recently identified and cloned a novel human gene, Che-1, whose product interacts with both RNA polymerase II and the retinoblastoma gene product (Rb). Furthermore, we found that Che-1 overexpression counteracts the growth inhibitory effects of Rb, regulating in such way both transcription and cell proliferation. In this paper, we describe the genomic organization of the mouse orthologous Che-1 gene and its promoter region. The promoter is TATA less and presents several potential transcription factor-binding motifs. Importantly, we showed that Che-1 expression is regulated by a negative feedback mechanism, in which this protein is present on its own promoter repressing transcription. (C) 2003 Elsevier B.V. All rights reserved.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/48592

Titolo:	Genomic structure and transcriptional regulation of Che-1, a novel partner of Rb
Autori interni:	MONACO, Lucia
Data di pubblicazione:	2003
Rivista:	GENE
Abstract:	We recently identified and cloned a novel human gene, Che-1, whose product interacts with both RNA polymerase II and the retinoblastoma gene product (Rb). Furthermore, we found that Che-1 overexpression counteracts the growth inhibitory effects of Rb, regulating in such way both transcription and cell proliferation. In this paper, we describe the genomic organization of the mouse orthologous Che-1 gene and its promoter region. The promoter is TATA less and presents several potential transcription factor-binding motifs. Importantly, we showed that Che-1 expression is regulated by a negative feedback mechanism, in which this protein is present on its own promoter repressing transcription. (C) 2003 Elsevier B.V. All rights reserved.
Handle:	http://hdl.handle.net/11573/48592
Appare nelle tipologie:	01.a Pubblicazione su Rivista

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