BACKGROUND: To study gonadal function in young patients suffering from left varicocele. METHODS: Design: prospective study. Setting: university laboratory and clinical services. Patients: 20 boys (age range: 15-20 yrs; mean +/- DS: 17.9 +/- 1.48 yrs), affected by left idiopathic varicocele. Intervention: high purified urinary FSH s.c. (Metrodin HP 75, Ares-Serono), three times every week, for three months. Main outcome measures: seminal fluid examination before and after therapy (WHO). RESULTS: At the end of the study period a statistically increase of sperm density/ml (38.45 x 10(6) vs 49.10 x 10(6), total sperm number/ejaculate with forward motility (37.41 x 10(6) vs 48.52 x 10(6)) and a decrease of atypical forms (54.35% vs 49.60%) has been observed; the increase of the total sperm number/ejaculate after FSH treatment greater than 50% compared with basal values allows to define 9 patients as responders. CONCLUSIONS: In this study the FSH treatment in young people with varicocele leads to a statistically significant increase in the seminal fluid parameters and may characterize a group of patients who may have a better prognostic outcome regarding the tubular gonadal function and thus the fertility potential in adult life.

The use of FSH in adolescents and young adults with idiopathic, unilateral, left varicocele not undergoing surgical intervention. Preliminary study / Radicioni, Antonio; Schwarzenberg, Tl. - In: MINERVA ENDOCRINOLOGICA. - ISSN 0391-1977. - STAMPA. - 24:(1999), pp. 63-68.

The use of FSH in adolescents and young adults with idiopathic, unilateral, left varicocele not undergoing surgical intervention. Preliminary study

RADICIONI, Antonio;
1999

Abstract

BACKGROUND: To study gonadal function in young patients suffering from left varicocele. METHODS: Design: prospective study. Setting: university laboratory and clinical services. Patients: 20 boys (age range: 15-20 yrs; mean +/- DS: 17.9 +/- 1.48 yrs), affected by left idiopathic varicocele. Intervention: high purified urinary FSH s.c. (Metrodin HP 75, Ares-Serono), three times every week, for three months. Main outcome measures: seminal fluid examination before and after therapy (WHO). RESULTS: At the end of the study period a statistically increase of sperm density/ml (38.45 x 10(6) vs 49.10 x 10(6), total sperm number/ejaculate with forward motility (37.41 x 10(6) vs 48.52 x 10(6)) and a decrease of atypical forms (54.35% vs 49.60%) has been observed; the increase of the total sperm number/ejaculate after FSH treatment greater than 50% compared with basal values allows to define 9 patients as responders. CONCLUSIONS: In this study the FSH treatment in young people with varicocele leads to a statistically significant increase in the seminal fluid parameters and may characterize a group of patients who may have a better prognostic outcome regarding the tubular gonadal function and thus the fertility potential in adult life.
1999
varicocele; gonadal function; FSH-teraphy
01 Pubblicazione su rivista::01a Articolo in rivista
The use of FSH in adolescents and young adults with idiopathic, unilateral, left varicocele not undergoing surgical intervention. Preliminary study / Radicioni, Antonio; Schwarzenberg, Tl. - In: MINERVA ENDOCRINOLOGICA. - ISSN 0391-1977. - STAMPA. - 24:(1999), pp. 63-68.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/485070
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