The aim of our study was to evaluate the occurrence of middle and long-term chronic renal failure (CRF) after orthotopic liver transplantation (OLT) in relation to acute renal failure (ARF). We prospectively monitored 75 patients, studying renal function on the basis of serum creatinine and glomerular filtration rate as estimated using the Modification of Diet in Renal Disease formula before as well as 1,6, and 12 months after OLT. The prevalence of ARF was 56% classified by the Acute Kidney injury Network criteria (52% stage 1, 29% stage 2, and 19% stage 3). The occurrences of CRF were 18.6% (11/59), 11.5% (6/52), and 14% (6/43) at 1, 6, and 12 months after OLT, respectively. The occurrence of CRF before OLT was 14.7%. We did not find any association between ARF and post-OLT CRF. The most relevant result of our study was the association between CRF at 6 and 12 months after transplantation with pre-OLT CRF on univariate and multivariate analysis. We suggest that evaluation of pre-OLT renal function should always be considered in the follow-up of liver transplant patients. Pre-OLT renal dysfunction must be recognized to be a risk factor for post-OLT CRF, representing important criterion to define specific therapeutic interventions to reduce patient morbidity and mortality. © 2012 Published by Elsevier Inc.

Occurrence of Chronic Renal Failure in Liver Transplantation: Monitoring of Pre- and Posttransplantation Renal Function / Umbro, Ilaria; Tinti, Francesca; P., Piselli; F., Fiacco; Giannelli, Valerio; V., Di Natale; A., Zavatto; Merli, Manuela; Rossi, Massimo; GINANNI CORRADINI, Stefano; Poli, Luca; Berloco, Pasquale Bartolomeo; Mitterhofer, Anna Paola. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - STAMPA. - 44:7(2012), pp. 1956-1959. (Intervento presentato al convegno 35th Annual Congress of the Italian-Society-of-Organ-Transplantation (SITO) tenutosi a Rome, ITALY nel OCT 27-29, 2011) [10.1016/j.transproceed.2012.06.012].

Occurrence of Chronic Renal Failure in Liver Transplantation: Monitoring of Pre- and Posttransplantation Renal Function

UMBRO, ILARIA;TINTI, FRANCESCA;GIANNELLI, VALERIO;MERLI, Manuela;ROSSI, MASSIMO;GINANNI CORRADINI, Stefano;POLI, Luca;BERLOCO, Pasquale Bartolomeo;MITTERHOFER, Anna Paola
2012

Abstract

The aim of our study was to evaluate the occurrence of middle and long-term chronic renal failure (CRF) after orthotopic liver transplantation (OLT) in relation to acute renal failure (ARF). We prospectively monitored 75 patients, studying renal function on the basis of serum creatinine and glomerular filtration rate as estimated using the Modification of Diet in Renal Disease formula before as well as 1,6, and 12 months after OLT. The prevalence of ARF was 56% classified by the Acute Kidney injury Network criteria (52% stage 1, 29% stage 2, and 19% stage 3). The occurrences of CRF were 18.6% (11/59), 11.5% (6/52), and 14% (6/43) at 1, 6, and 12 months after OLT, respectively. The occurrence of CRF before OLT was 14.7%. We did not find any association between ARF and post-OLT CRF. The most relevant result of our study was the association between CRF at 6 and 12 months after transplantation with pre-OLT CRF on univariate and multivariate analysis. We suggest that evaluation of pre-OLT renal function should always be considered in the follow-up of liver transplant patients. Pre-OLT renal dysfunction must be recognized to be a risk factor for post-OLT CRF, representing important criterion to define specific therapeutic interventions to reduce patient morbidity and mortality. © 2012 Published by Elsevier Inc.
2012
risk-factors; chronic kidney-disease; survival
01 Pubblicazione su rivista::01a Articolo in rivista
Occurrence of Chronic Renal Failure in Liver Transplantation: Monitoring of Pre- and Posttransplantation Renal Function / Umbro, Ilaria; Tinti, Francesca; P., Piselli; F., Fiacco; Giannelli, Valerio; V., Di Natale; A., Zavatto; Merli, Manuela; Rossi, Massimo; GINANNI CORRADINI, Stefano; Poli, Luca; Berloco, Pasquale Bartolomeo; Mitterhofer, Anna Paola. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - STAMPA. - 44:7(2012), pp. 1956-1959. (Intervento presentato al convegno 35th Annual Congress of the Italian-Society-of-Organ-Transplantation (SITO) tenutosi a Rome, ITALY nel OCT 27-29, 2011) [10.1016/j.transproceed.2012.06.012].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/484884
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