OBJECTIVE-To evaluate the celiac-associated humoral autoimmunity in child, adolescent, and adult patients at type 1 diabetes (DM1) onset and to determine whether DM1 celiac-specific humoral immunoreactivity occurs similarly to that in nondiabetic patients at celiac disease (CD) diagnosis. RESEARCH DESIGN AND METHODS-IgA anti-transglutaminase autoantibody (IgA-tTGAb) was detected in 654 new-onset DM1 sera. IgA-tTGAb DM1 sera were subsequently analyzed for IgG-tTG, deamidated gliadin (DGP), and actin antibodies, and results were compared with those found in 83 screen-detected nondiabetic patients at CD diagnosis. RESULTS-A total of 12.8% DM1 sera were IgA-TGAb(+), with a lower autoantibody frequency in adult patients aged >18 years (6.8 vs. 15.1%, aged <= 18 years; P = 0.005). IgA-tTGAb titers, IgG-tTGAb, and DGPAb frequency/titers and mean number of celiac-autoantibody positivities per patient were significantly lower in IgA-tTGAb(+) DM1 compared with nondiabetic CD patients. CONCLUSIONS-Age of diabetes onset is negatively associated with risk of CD. The celiac-specific humoral immunoreactivity at DM1 onset is significantly lower compared with that found in nondiabetic patients at CD diagnosis. Diabetes Care 35:2083-2085, 2012

IgA Anti-transglutaminase Autoantibodies at Type 1 Diabetes Onset Are Less Frequent in Adult Patients and Are Associated With a General Celiac-Specific Lower Immune Response in Comparison With Nondiabetic Celiac Patients at Diagnosis / Tiberti, Claudio; Panimolle, Francesca; Bonamico, Margherita; B., Shashaj; Filardi, Tiziana; Lucantoni, Federica; Nenna, Raffaella; F., Costantino; Lenzi, Andrea; Morano, Susanna. - In: DIABETES CARE. - ISSN 0149-5992. - STAMPA. - 35:10(2012), pp. 2083-2085. [10.2337/dc11-2171]

IgA Anti-transglutaminase Autoantibodies at Type 1 Diabetes Onset Are Less Frequent in Adult Patients and Are Associated With a General Celiac-Specific Lower Immune Response in Comparison With Nondiabetic Celiac Patients at Diagnosis

TIBERTI, Claudio;PANIMOLLE, FRANCESCA;BONAMICO, Margherita;FILARDI, TIZIANA;LUCANTONI, Federica;NENNA, RAFFAELLA;LENZI, Andrea;MORANO, Susanna
2012

Abstract

OBJECTIVE-To evaluate the celiac-associated humoral autoimmunity in child, adolescent, and adult patients at type 1 diabetes (DM1) onset and to determine whether DM1 celiac-specific humoral immunoreactivity occurs similarly to that in nondiabetic patients at celiac disease (CD) diagnosis. RESEARCH DESIGN AND METHODS-IgA anti-transglutaminase autoantibody (IgA-tTGAb) was detected in 654 new-onset DM1 sera. IgA-tTGAb DM1 sera were subsequently analyzed for IgG-tTG, deamidated gliadin (DGP), and actin antibodies, and results were compared with those found in 83 screen-detected nondiabetic patients at CD diagnosis. RESULTS-A total of 12.8% DM1 sera were IgA-TGAb(+), with a lower autoantibody frequency in adult patients aged >18 years (6.8 vs. 15.1%, aged <= 18 years; P = 0.005). IgA-tTGAb titers, IgG-tTGAb, and DGPAb frequency/titers and mean number of celiac-autoantibody positivities per patient were significantly lower in IgA-tTGAb(+) DM1 compared with nondiabetic CD patients. CONCLUSIONS-Age of diabetes onset is negatively associated with risk of CD. The celiac-specific humoral immunoreactivity at DM1 onset is significantly lower compared with that found in nondiabetic patients at CD diagnosis. Diabetes Care 35:2083-2085, 2012
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IgA Anti-transglutaminase Autoantibodies at Type 1 Diabetes Onset Are Less Frequent in Adult Patients and Are Associated With a General Celiac-Specific Lower Immune Response in Comparison With Nondiabetic Celiac Patients at Diagnosis / Tiberti, Claudio; Panimolle, Francesca; Bonamico, Margherita; B., Shashaj; Filardi, Tiziana; Lucantoni, Federica; Nenna, Raffaella; F., Costantino; Lenzi, Andrea; Morano, Susanna. - In: DIABETES CARE. - ISSN 0149-5992. - STAMPA. - 35:10(2012), pp. 2083-2085. [10.2337/dc11-2171]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/484646
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