The purpose of this study was to shed light on the neurochemical modulatory mechanisms of the noxious spinal inhibitory cutaneous silent period (CSP). We study the effects of 100 mg of oral tramadol in 11 healthy volunteers. Tramadol has low affinity for opioid receptors and has the ability to inhibit serotonin and noradrenaline reuptake. We elicited CSPs in the first dorsal interosseus muscle and noxious withdrawal flexor reflexes (NWR) in the right biceps femoris muscle before, 30 min and each hour up to the 6th after tramadol. Subjective pain sensation was checked on an 11-point numerical scale. Tramadol increased duration of CSP, and reduced the NWR area under the curve maximally 2 h after tramadol and paralleled the reduction of subjective pain perception. We suggest that the monoaminergic action of tramadol reinforces the activity of spinal inhibitory interneurons on alpha-motoneurons for the hand muscles. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

Cutaneous silent period in hand muscles is lengthened by tramadol: Evidence for monoaminergic modulation? / Pujia, Francesco; Coppola, Gianluca; Anastasio, MARIA GRAZIA; Brienza, Marianna; Elisa, Vestrini; Valente, Gabriele Oreste Renato; Parisi, Leoluca; Serrao, Mariano; Pierelli, Francesco. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - STAMPA. - 528:1(2012), pp. 78-82. [10.1016/j.neulet.2012.08.064]

Cutaneous silent period in hand muscles is lengthened by tramadol: Evidence for monoaminergic modulation?

PUJIA, FRANCESCO;COPPOLA, GIANLUCA;ANASTASIO, MARIA GRAZIA;Marianna Brienza;VALENTE, Gabriele Oreste Renato;PARISI, Leoluca;SERRAO, Mariano;PIERELLI, Francesco
2012

Abstract

The purpose of this study was to shed light on the neurochemical modulatory mechanisms of the noxious spinal inhibitory cutaneous silent period (CSP). We study the effects of 100 mg of oral tramadol in 11 healthy volunteers. Tramadol has low affinity for opioid receptors and has the ability to inhibit serotonin and noradrenaline reuptake. We elicited CSPs in the first dorsal interosseus muscle and noxious withdrawal flexor reflexes (NWR) in the right biceps femoris muscle before, 30 min and each hour up to the 6th after tramadol. Subjective pain sensation was checked on an 11-point numerical scale. Tramadol increased duration of CSP, and reduced the NWR area under the curve maximally 2 h after tramadol and paralleled the reduction of subjective pain perception. We suggest that the monoaminergic action of tramadol reinforces the activity of spinal inhibitory interneurons on alpha-motoneurons for the hand muscles. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
2012
brainstem descending system; cutaneous silent period; monoamines; noxious withdrawal flexor reflex; tramadol
01 Pubblicazione su rivista::01a Articolo in rivista
Cutaneous silent period in hand muscles is lengthened by tramadol: Evidence for monoaminergic modulation? / Pujia, Francesco; Coppola, Gianluca; Anastasio, MARIA GRAZIA; Brienza, Marianna; Elisa, Vestrini; Valente, Gabriele Oreste Renato; Parisi, Leoluca; Serrao, Mariano; Pierelli, Francesco. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - STAMPA. - 528:1(2012), pp. 78-82. [10.1016/j.neulet.2012.08.064]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/484269
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