Multicomponent envelope-type lipid nanosystem (MENS) is an emerging nanoparticle technology. These nanoparticles were assembled according to a recently proposed 'programmed packaging concept' in which various devices that control intracellular trafficking are packed into a single multicomponent envelope-type nanoparticle system. The uptake ability and final intracellular fate of MENS formulations was evaluated by means of confocal laser scannig microscopy. Our results revealed that MENS show a high cellular internalization and that are not specifically targeted to metabolic degradation. These studies will contribute to rationally design novel delivery systems with superior transfection efficiency.
Surface functionalized multicomponent envelope type nanosystems for improved gene delivery / Pozzi, Daniela; Orlando, Viviana; Gabriella Augusti, Tocco; Biagioni, Stefano; Francesco, Cardarelli; Angelo, Bifone; F., Salomone; Caracciolo, Giulio. - ELETTRONICO. - (2012), pp. 146-149. (Intervento presentato al convegno Nanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012 tenutosi a Santa Clara; United States nel 18 June 2012 through 21 June 2012).
Surface functionalized multicomponent envelope type nanosystems for improved gene delivery
POZZI, DANIELA;ORLANDO, Viviana;BIAGIONI, Stefano;CARACCIOLO, Giulio
2012
Abstract
Multicomponent envelope-type lipid nanosystem (MENS) is an emerging nanoparticle technology. These nanoparticles were assembled according to a recently proposed 'programmed packaging concept' in which various devices that control intracellular trafficking are packed into a single multicomponent envelope-type nanoparticle system. The uptake ability and final intracellular fate of MENS formulations was evaluated by means of confocal laser scannig microscopy. Our results revealed that MENS show a high cellular internalization and that are not specifically targeted to metabolic degradation. These studies will contribute to rationally design novel delivery systems with superior transfection efficiency.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
