A procedure is presented for the automatic determination of the amino acid sequence of peptides by processing data obtained from mass spectrometry analysis. This is a basic and relevant problem in the field of proteomics. Furthermore, it. has an even higher conceptual and applicative interest in peptide research, as well as in other connected fields. The analysis does not rely on known protein databases, but oil the computation of all amino acid sequences compatible with the given spectral data. By formulating a mathematical model for such combinatorial problems, the structural limitations of known methods are overcome, and efficient solution algorithms can be developed. The results are very encouraging both from the accuracy and computational points of view. Copyright (c) 2004 European Peptide Society and John Wiley & Sons, Ltd.
On peptide de novo sequencing: a new approach / Bruni, Renato; Gianluigi, Gianfranceschi; Giorgio, Koch. - In: JOURNAL OF PEPTIDE SCIENCE. - ISSN 1075-2617. - STAMPA. - 11:4(2005), pp. 225-234. [10.1002/psc.595]
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Titolo: | On peptide de novo sequencing: a new approach | |
Autori: | ||
Data di pubblicazione: | 2005 | |
Rivista: | ||
Citazione: | On peptide de novo sequencing: a new approach / Bruni, Renato; Gianluigi, Gianfranceschi; Giorgio, Koch. - In: JOURNAL OF PEPTIDE SCIENCE. - ISSN 1075-2617. - STAMPA. - 11:4(2005), pp. 225-234. [10.1002/psc.595] | |
Handle: | http://hdl.handle.net/11573/483212 | |
Appartiene alla tipologia: | 01a Articolo in rivista |
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