In the present work, we report the synthesis of the novel esters of indomethacin (IDMC) and an ester of reduced IDMC. For this purpose, IDMC is covalently bound by using a spacer chain to the pyrrole (Py) in the 3-position. The innovative pyrrole-indomethacin (3-Py-IDMC) derivates show no cytotoxic effects in primary calvarial osteoblasts. The designed IDMC derivates have been studied because they could be injected locally as a component of polymeric micro-particles. In fact, the new 3-Py-IDMC derivatives will assure their further polymerization since the 2- and 5-monomer positions are free. © 2012 Elsevier Masson SAS. All rights reserved.
Synthesis of novel pyrrolyl-indomethacin derivatives / SERRA MORENO, Judit; Agas, Dimitrios; Maria Giovanna, Sabbieti; Matteo Di, Magno; Migliorini, Antonella; Loreto, Maria Antonietta; M., Antonietta Loreto. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - STAMPA. - 57:(2012), pp. 391-397. [10.1016/j.ejmech.2012.09.008]
Synthesis of novel pyrrolyl-indomethacin derivatives
SERRA MORENO, JUDIT;AGAS, DIMITRIOS;MIGLIORINI, Antonella;LORETO, Maria Antonietta;
2012
Abstract
In the present work, we report the synthesis of the novel esters of indomethacin (IDMC) and an ester of reduced IDMC. For this purpose, IDMC is covalently bound by using a spacer chain to the pyrrole (Py) in the 3-position. The innovative pyrrole-indomethacin (3-Py-IDMC) derivates show no cytotoxic effects in primary calvarial osteoblasts. The designed IDMC derivates have been studied because they could be injected locally as a component of polymeric micro-particles. In fact, the new 3-Py-IDMC derivatives will assure their further polymerization since the 2- and 5-monomer positions are free. © 2012 Elsevier Masson SAS. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
