The available estimate of the energy expended for signaling in rat neocortex is refined to examine the separate contribution of spiking and synaptic activity as a function of average neuronal firing rate. By taking into account a phenomenological model of short-term synaptic plasticity, we show that the transition from low to high cortical activity is accompanied by a substantial increase in relative energy consumed by action potentials vs. synaptic potentials. This consideration might be important for a deeper understanding of how information is represented in the cortex and which metabolic pathways are upregulated to sustain cortical activity. (c) 2012 Wiley Periodicals, Inc.
Activity-dependent energy budget for neocortical signaling: Effect of short-term synaptic plasticity on the energy expended by spiking and synaptic activity / Mauro, Dinuzzo; Giove, Federico. - In: JOURNAL OF NEUROSCIENCE RESEARCH. - ISSN 0360-4012. - STAMPA. - 90:11(2012), pp. 2094-2102. [10.1002/jnr.23098]
Activity-dependent energy budget for neocortical signaling: Effect of short-term synaptic plasticity on the energy expended by spiking and synaptic activity
GIOVE, FEDERICO
2012
Abstract
The available estimate of the energy expended for signaling in rat neocortex is refined to examine the separate contribution of spiking and synaptic activity as a function of average neuronal firing rate. By taking into account a phenomenological model of short-term synaptic plasticity, we show that the transition from low to high cortical activity is accompanied by a substantial increase in relative energy consumed by action potentials vs. synaptic potentials. This consideration might be important for a deeper understanding of how information is represented in the cortex and which metabolic pathways are upregulated to sustain cortical activity. (c) 2012 Wiley Periodicals, Inc.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.