Background: No recent national-level data on the aetiology of chronic hepatitis are available in Italy. Aim: To evaluate the current aetiology of chronic hepatitis in Italy. Patients: A total of 6210 chronic hepatitis patients (both prevalence and incident cases) consecutively admitted to 79 hospitals located throughout Italy were enrolled over a 6-month period in 2001. The hospitals were randomly selected through systematic cluster sampling. Results: The main agent associated with chronic hepatitis was hepatitis C virus, which was found in 76.5% of the patients (in 62.6% it was the only aetiologic factor). Hepatitis B surface antigen was present in the serum of 12.2% of the cases (in 9.2% it was the only aetiologic factor). Hepatitis B e antigen and hepatitis Delta were detected in 16.6% and 7.0%, respectively, of hepatitis B surface antigen-positive patients. A history of alcohol abuse was found in 19.2% of the cases (5.5% without viral infection). Autoimmune hepatitis and inborn metabolic disorders were extremely rare. The prevalence of hepatitis C virus-related cases was significantly lower in incident cases, compared to prevalent cases (55.1% versus 65.0%; p < 0.01). The mean alanine aminotransferase level was significantly higher in hepatitis B surface antigen-positive patients, compared to hepatitis B surface antigen-negative patients. The histology was less severe in non-viral-related cases. Conclusions: Hepatitis C virus is the most important pathogenic factor for chronic hepatitis in Italy; however, the comparison between prevalent and incident cases suggests that this infection will play a less important role in the future. A comparison with previous reports shows that both hepatitis B virus-related and hepatitis Delta virus-related cases are decreasing. © 2004 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
The aetiology of chronic hepatitis in Italy: Results from a multicentre national study / T., Stroffolini; E., Sagnelli; A., Mele; A., Craxi; P., Almasio; A., Traverso; A., Arrigoni; M., Torchio; P., Garbagnoli; B., Del Mastro; P., Romano; R., Vanni; D., Brusita; P., Meucci; G., Cassola; M., Borzio; A., Bellobuono; A., De Bona; T., Re; P., Del Poggio; O., Baisini; A., Colombo; C., Attolini; Daria, Sacchini; L., Minoli; V., Gazzaniga; S., Segato; M., Oriolo; A., Parlotto; M., Ghersetti; F., Capra; R., Muratori; C., Sama; S., Boccia; G., Verdianelli; A., Pratico; M., Grandi; E., Ventura; F., Cantoni; A., Vincenti; A., Nerli Alessandro; L., Galeazzi; A., Solinas; Paroli, Marino; G. M., De Sanctis; S., Sereno; C., Clementi; U., Visco Comandino; A. I., Gallo; D., Festi; G., Sabusco; N., Coppola; C., Scolastico; M., Onofrio; M., Imparato; P., Filippini; F., Morisco; A., Liberti; G., Borgia; F., Scarpellino; M., Persico; C., Sagnelli; C., Coppola; L., Caserta; A., Elia; G., De Vita; A., Lanzotti; L., Pizzolante; V., Messina; G., Fiore; E., Agostinacchio; T., Santantonio; M., Mazzola; F., Vinelli; A., Campagna; S., Cataldini; I., Monelli; M., Lascaro; N., Polimeri; P., Frigiuele; M., Ferraro; T., Prestileo; A., Alessandri; M., Russello Maurizio; P., Bellissima; G., Orifici; G., Pisani; S., Angioini; M., Lai; M., Spanneda. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - STAMPA. - 36:12(2004), pp. 829-833. [10.1016/j.dld.2004.07.013]
The aetiology of chronic hepatitis in Italy: Results from a multicentre national study
PAROLI, Marino;
2004
Abstract
Background: No recent national-level data on the aetiology of chronic hepatitis are available in Italy. Aim: To evaluate the current aetiology of chronic hepatitis in Italy. Patients: A total of 6210 chronic hepatitis patients (both prevalence and incident cases) consecutively admitted to 79 hospitals located throughout Italy were enrolled over a 6-month period in 2001. The hospitals were randomly selected through systematic cluster sampling. Results: The main agent associated with chronic hepatitis was hepatitis C virus, which was found in 76.5% of the patients (in 62.6% it was the only aetiologic factor). Hepatitis B surface antigen was present in the serum of 12.2% of the cases (in 9.2% it was the only aetiologic factor). Hepatitis B e antigen and hepatitis Delta were detected in 16.6% and 7.0%, respectively, of hepatitis B surface antigen-positive patients. A history of alcohol abuse was found in 19.2% of the cases (5.5% without viral infection). Autoimmune hepatitis and inborn metabolic disorders were extremely rare. The prevalence of hepatitis C virus-related cases was significantly lower in incident cases, compared to prevalent cases (55.1% versus 65.0%; p < 0.01). The mean alanine aminotransferase level was significantly higher in hepatitis B surface antigen-positive patients, compared to hepatitis B surface antigen-negative patients. The histology was less severe in non-viral-related cases. Conclusions: Hepatitis C virus is the most important pathogenic factor for chronic hepatitis in Italy; however, the comparison between prevalent and incident cases suggests that this infection will play a less important role in the future. A comparison with previous reports shows that both hepatitis B virus-related and hepatitis Delta virus-related cases are decreasing. © 2004 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
